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AEBSF

Catalog #: 5175
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AEBSF | CAS No. 30827-99-7 | Additional Synthetic Protease Inhibitors
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Description: Broad spectrum, irreversible inhibitor of serine proteases

Chemical Name: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AEBSF is a broad spectrum, irreversible inhibitor of serine proteases. Also inhibits NADPH oxidase activation in vitro. Attenuates airway inflammation in a mouse model of airway allergy.

Technical Data

M.Wt:
239.69
Formula:
C8H10FNO2S.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
30827-99-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Activated hepatic stellate cells are dependent on self-collagen, cleaved by membrane type 1 matrix metalloproteinase for their growth.
    Birukawa N, Murase K, Sato Y, Kosaka A, Yoneda A, Nishita H, Fujita R, Nishimura M, Ninomiya T, Kajiwara K, Miyazaki M, Nakashima Y, Ota S, Murakami Y, Tanaka Y, Minomi K, Tamura Y, Niitsu Y
    J Biol Chem, 2014;289(29):20209-21.
  2. Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds.
    Diatchuk et al.
    J.Biol.Chem., 1997;272:13292
  3. Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease.
    Saw et al.
    PLoS ONE, 2012;7:e41107

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Citation for AEBSF

The citations listed below are publications that use Tocris products. Selected citations for AEBSF include:

1 Citation: Showing 1 - 1

  1. Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects.
    Authors: Xianglan Et al.
    J Allergy Clin Immunol  2019;144:426-441.e3

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