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A 410099.1, amine

Catalog #: 6471
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6471/100
A 410099.1, amine | CAS No. 2374122-37-7 | Degrader Building Blocks
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Description: Functionalized IAP ligand for PROTACs

Chemical Name: tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-amino-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate hydrochloride

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

A 410099.1, amine is a functionalized IAP ligand for PROTAC® research and development. Boc protected A 410099.1 (Cat.No. 6470). Supplied with an amine functional handle for ready conjugation to a linker/target protein ligand. NanoBRET assays show EC50 values of 4.6, 9.2 and 15.6 nM for cIAP1, cIAP2 and XIAP proteins, respectively. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
620.22
Formula:
C32H49N5O5.HCl
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2374122-37-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding.
    Tinworth et al.
    ACS Chem.Biol., 2019;14:342

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Citations for A 410099.1, amine

The citations listed below are publications that use Tocris products. Selected citations for A 410099.1, amine include:

2 Citations: Showing 1 - 2

  1. A toolbox for the generation of chemical probes for baculovirus IAP repeat containing proteins.
    Authors: Schwalm Et al.
    Front.Cell.Dev.Biol.  2022;10:886537
  2. Perfluorooctanoic acid (PFOA) exposure promotes proliferation, migration and invasion potential in human breast epithelial cells.
    Authors: Oskar Et al.
    Arch Toxicol  2018;92:1729-1739

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