A 410099.1
Chemical Name: N-Methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-L-prolinamide hydrochloride
Purity: ≥98%
Biological Activity
A 410099.1 is a high affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia.
Loeder S, Zenz T, Schnaiter A et al.
Cancer Res -
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
Oost et al.
J.Med.Chem., 2004;47:4417
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Citation for A 410099.1
The citations listed below are publications that use Tocris products. Selected citations for A 410099.1 include:
1 Citation: Showing 1 - 1
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A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins.
Authors: Susanne Et al.
Front Cell Dev Biol 2022;10:886537
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