4F 4PP oxalate
Chemical Name: 4-(4-Fluorobenzoyl)-1-(4-phenylbutyl)piperidine oxalate
Purity: ≥99%
Biological Activity
4F 4PP oxalate is a selective 5-HT2A antagonist with almost as high affinity (Ki = 5.3 nM) as Ketanserin (Cat. No. 0908) but with a much lower affinity for 5-HT2C sites (Ki = 620 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
Hagberg et al.
Neurochem.Int., 1998;32:153 -
Ketanserin analogues - structure affinity relationships of 5HT2 and 5HT1C serotonin receptor binding.
Herndon et al.
J.Med.Chem., 1992;35:4903
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Citations for 4F 4PP oxalate
The citations listed below are publications that use Tocris products. Selected citations for 4F 4PP oxalate include:
3 Citations: Showing 1 - 3
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Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors.
Authors: Rodríguez-Muñoz Et al.
Oncotarget 2018;9:23373
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Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice.
Authors: Lee Et al.
J Allergy Clin Immunol 2018;142:1349
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Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
Authors: Gerhold Et al.
J Neurosci 2015;35:9580
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