Ketanserin tartrate
Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione tartrate
Purity: ≥97%
Biological Activity
Ketanserin tartrate is a selective 5-HT2A serotonin receptor antagonist; can also be used to discriminate between 5-HT1D and 5-HT1B receptor subtypes.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Receptor binding profile of R41 468, a novel antagonist at 5-HT2 receptors.
Leyson et al.
Life Sci., 1981;28:1015 -
Differences in the effects of ketanserin and GR 127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein.
Razzaque et al.
Eur.J.Pharmacol., 1995;283:199 -
Vascular effects of ketanserin (R41 468), a novel antagonist of 5-HT2 serotonergic receptors.
Van Nueten et al.
J.Pharmacol.Exp.Ther., 1981;218:217 -
Ketanserin and ritanserin discriminate between recombinant human 5-HT1Dα and 5-HT1Dβ receptor subtypes.
Zgombick et al.
Eur.J.Pharmacol., 1995;291:9
Product Datasheets
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Citations for Ketanserin tartrate
The citations listed below are publications that use Tocris products. Selected citations for Ketanserin tartrate include:
23 Citations: Showing 1 - 10
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High and hyper: fentanyl induces psychomotor side-effects in healthy pigs.
Authors: Digranes Et al.
Animals 2023;13:1671
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Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.
Authors: Nguyen Et al.
Korean J Physiol Pharmacol 2019;23:271
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Maternal Regulation of Pups' Cortical Activity: Role of Serotonergic Signaling.
Authors: Courtiol Et al.
Eneuro 2018;5
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Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
Authors: Medrihan Et al.
Neuron 2017;95:564
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Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
Authors: Hirono
Neuropharmacology 2017;118:79
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Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors.
Authors: Jiang Et al.
Br J Pharmacol 2015;89:342
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Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens.
Authors: Kasper Et al.
Neuropharmacology 2015;69:78
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Behavioral and neurochemical changes in mesostriatal DArgic regions of the rat after chronic administration of the cannabinoid receptor agonist WIN55,212-2.
Authors: Fanarioti Et al.
Synapse 2015;18
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A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases.
Authors: Kuo Et al.
Int J Biol Sci 2014;10:64
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Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival.
Authors: Saxena Et al.
Neuron 2013;80:80
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Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass.
Authors: Ratner Et al.
Neuron 2012;20:2133
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Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension.
Authors: Morecroft Et al.
Cereb Cortex 2012;20:1516
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Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production.
Authors: Wood Et al.
J Neurosci 2011;31:13808
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Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster.
Authors: Johnson Et al.
Neuroscience 2011;192:372
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Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation.
Authors: Kleinbongard Et al.
Circ Res 2011;108:344
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In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.
Authors: Morecroft Et al.
Int J Neuropsychopharmacol 2010;85:593
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Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex.
Authors: Huang Et al.
Neuropsychopharmacology 2009;34:1979
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Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses.
Authors: Watakabe Et al.
Br J Pharmacol 2009;19:1915
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Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat.
Authors: Mbaki
Br J Pharmacol 2008;155:343
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Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.
Authors: González-Maeso Et al.
Mol Ther 2007;53:439
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Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
Authors: Hampson Et al.
Diabetologia 2007;50:1743
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Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous.
Authors: Marinelli Et al.
J Neurophysiol 2004;92:3532
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5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor.
Authors: Morecroft Et al.
Obesity (Silver Spring) 1999;128:730
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