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Zardaverine

Catalog #: 1046
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1046/10
1046/50
Zardaverine | CAS No. 101975-10-4 | Phosphodiesterase Inhibitors
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Description: PDE3/4 inhibitor

Chemical Name: 6-[4-(Difluoromethoxy)-3-methoxyphenyl]-3(2H)-pyridazinone

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Zardaverine is a phosphodiesterase inhibitor, selective for PDE3 and 4 (IC50 values are 0.5 and 0.8 μM respectively).

Technical Data

M.Wt:
268.22
Formula:
C12H10F2N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
101975-10-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks D, Germain R, Kastner D, Chae J
    Nature, 2012;492(7427):123-7.
  2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  3. Is phosphodiesterase inhibition a relevant bronchospasmolytic principle?
    Kilian et al.
    Agents Actions Suppl., 1989;28:331
  4. Actions of the phosphodiesterase inhibitor zardaverine on guinea pig ventricular muscle.
    Galvan and Schudt
    Naunyn Schmiedebergs Arch.Pharmacol., 1990;342:221

Product Datasheets

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Citations for Zardaverine

The citations listed below are publications that use Tocris products. Selected citations for Zardaverine include:

4 Citations: Showing 1 - 4

  1. Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.
    Authors: Navarro Et al.
    J Neurosci  2015;35:6639
  2. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature  2012;492:123
  3. Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells.
    Authors: Gulyani Et al.
    Exp Neurol  2009;215:236
  4. Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea.
    Authors: Zerani Et al.
    Pain  2004;183:279

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