Zacopride hydrochloride

Catalog #: 1795
3 Citations Datasheet / COA / SDS

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Zacopride hydrochloride | CAS No. 101303-98-4 | 5-HT3 Receptor Antagonists

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Description: Highly potent 5-HT3 antagonist; also 5-HT4 agonist

Chemical Name: (±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamide hydrochloride

Purity: ≥99%

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Product Details

Citations (3)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Zacopride hydrochloride is a highly potent 5-HT₃ receptor antagonist (K_i = 0.38 nM) and 5-HT₄ receptor agonist (K_i = 373 nM). Antiemetic and anxiolytic following systemic administration in vivo.

Technical Data

M.Wt:

346.26

Formula:

C₁₅H₂₀ClN₃O₂.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥99%

Storage:

Desiccate at RT

CAS No:

101303-98-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrial functions

Sci Rep, 2016;6(0):37336.
Comparison of the 5-HT₃ receptor antagonist properties of ICS 205-930, GR38032F and zacopride.
Cohen et al.
J.Pharmacol.Exp.Ther., 1989;248:197
Zacopride: anxiolytic profile in rodent and primate models of anxiety.
Costall et al.
J.Pharm.Pharmacol., 1988;40:302
Effects of 5-HT₄-receptor agonists, cisapride, mosapride citrate, and zacopride, on cardiac action potentials in guinea pig isolated papillary muscles.
Kii and Ito
J.Cardiovasc.Pharmacol., 1997;29:670
Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT₄ receptor versus human 5-HT₃ receptor.
Nagakura et al.
Pharmacol.Res., 1999;39:375

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Citations for Zacopride hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Zacopride hydrochloride include:

3 Citations: Showing 1 - 3

5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrialfunctions
Authors: Wang Et al.
Scientific Reports 2016;6:37336
Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.
Authors: Otvos Et al.
Circulation 2015;7:2336
The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors.
Authors: Ding Et al.
Toxins (Basel) 2015;29:725

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