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YNT 185

Catalog #: 6739 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6739/10
YNT 185 | CAS No. 1804978-82-2 | OX2 Receptor Agonists
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Description: Potent and selective OX2 agonist

Chemical Name: 3'-[[[3-[[2-[[2-(Dimethylamino)benzoyl]amino]ethyl]amino]phenyl]amino]sulfonyl]-4'-methoxy-N,N-dimethyl-[1,1'-biphenyl]-3-carboxamide dihydrochloride

Purity: ≥98%

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Biological Activity

YNT 185 is a potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.

Technical Data

M.Wt:
688.66
Formula:
C33H37N5O5S.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1804978-82-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Design and synthesis of non-peptide, selective orexin receptor 2 agonists.
    Nagahara et al.
    J.Med.Chem., 2015;58:7931
  2. Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models.
    Irukayama-Tomobe et al.
    Proc.Natl.Acad.Sci.USA., 2017;144:5731

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