Home / Phospholipase Inhibitors / YM 26734

YM 26734

Catalog #: 2522
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2522/10
YM 26734 | CAS No. 144337-18-8 | Phospholipase Inhibitors
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Description: Secretory phospholipase A2 (sPLA2) inhibitor

Chemical Name: 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone

Purity: ≥95%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

YM 26734 is a competitive inhibitor of secretory phospholipase A2 (sPLA2) that exhibits a broad inhibitory profile to several sPLA2s (IC50 values are 0.2, 1, 1, 1 and 3 μM for sPLA2-X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA2-IIF and no activity at cytosolic PLA2, cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.

Technical Data

M.Wt:
730.97
Formula:
C45H62O8
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
144337-18-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for YM 26734

The citations listed below are publications that use Tocris products. Selected citations for YM 26734 include:

2 Citations: Showing 1 - 2

  1. Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity.
    Authors: Pernet Et al.
    Nat Commun  2014;5:5105
  2. Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2.
    Authors: Bianca Et al.
    Front Mol Neurosci  2010;161:1835

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