Home / Rho-kinase Inhibitors / Y-27632 dihydrochloride

Y-27632 dihydrochloride

Catalog #: 1254
251 Citations 3 Reviews Datasheet / COA / SDS
GMP Version Available: TB1254-GMP
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1254/1
Y-27632 dihydrochloride | CAS No. 129830-38-2 | Rho-kinase Inhibitors
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Description: Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component
Alternative Names: y27632, Y-27632 2HCl, ROCK inhibitor, ROCK1 inhibitor

Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride

Purity: ≥98%

Product Details
Citations (251)
Supplemental Products
Reviews (3)
Biological Activity Scientific Data Technical Data Background Product Datasheets Calculators

Biological Activity

Y-27632 dihydrochloride is a selective ROCK inhibitor (Ki values are 0.14-0.22, 0.3, 25, 26 and > 250 μM for ROCK1 (p160 ROCK), ROCK2, PKA, PKC and MLCK respectively). Also inhibits PRK2 (IC50 = 600 nM). Increases survival rate of human embryonic stem (hES) cells and iPSC undergoing cryopreservation. Used in combination with CHIR99021, RepSox, Forskolin, SP 600125, Go 6983 and VPA to reprogram fibroblasts to mature neurons. Also optimizes naive human pluripotent stem cell growth and viability following naive cell derivation from primed ESCs and iPSCs using naive human stem cell medium (NHSM). Used as component of growth media for urothelial organoids. Also used in a protocol to generate brain organoids from human iPSCs. Cell-permeable, orally bioavailable and active in vivo.

Y-27632 synthesized to cGMP guidelines also available.

For more information about how Y-27632 dihydrochloride may be used, see our protocols: Transdifferentiating Fibroblasts into Neurons, Converting Fibroblasts into Cardiomyocytes (9C Cocktail), Accelerated Induction of Cortical Neurons from hiPSCs, Human iPSC-derived Myoblasts.

Scientific Data

N/A ROCK inhibition by Y-27632 and immunostaining of skeletal myogenic differentiation of MESP1+ mesoderm, View Larger

Application of Y-27632 in MESP1+ Mesoderm. ROCK inhibition by Y-27632 (1 μM) promotes skeletal myogenic differentiation of MESP1+ mesoderm, as shown by immunostaining for Myosin Heavy Chain+ (Green) and Myogenin (Red), and counterstaining with DAPI (Catalog # 5748; Blue, Tocris). Data courtesy of Dr Sunny Chan and Dr Michael Kyba, University of Minnesota.

Technical Data

M.Wt:
320.26
Formula:
C14H21N3O.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
129830-38-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Derivation of novel human ground state naive pluripotent stem cells.
    Gafni O, Weinberger L, Mansour AA et al.
    Nature
  2. Cryopreservation of brain endothelial cells derived from human induced pluripotent stem cells is enhanced by Rho-associated coiled coil-containing kinase inhibition.
    Wilson et al.
    Tissue.Eng.Part C.Methods, 2016;22:1085
  3. Development of bipotent cardiac/skeletal myogenic progenitors from MESP1+ mesoderm.
    Chan et al.
    Stem Cell Reports, 2016;6:26
  4. Freeze-thawing single human embryonic stem cells induce e-cadherin and actin filament network disruption via g13 signaling.
    Ichikawa et al.
    Cryo Letters., 2011;32:516
  5. Use and properties of ROCK-specific inhibitor Y-27632.
    Narumiya et al.
    Methods Enzymol., 2000;325:273
  6. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase.
    Uehata et al.
    Nature, 1997;389:990
  7. In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
    Bartfeld et al.
    Gastroenterology, 2015;148:126
  8. Generation of Cerebral Organoids from Human Pluripotent Stem Cells
    Lancaster et al.
    Nat.Protoc., 2015;9:2329
  9. SnapShot: Growing Organoids from Stem Cells.
    Sato et al.
    Cell, 2015;161:1700
  10. Establishment of gastrointestinal epithelial organoids
    Mahe et al.
    Curr.Protoc. Mouse Biol., 2014;3:217
  11. Human blood vessel organoids as a model of diabetic vasculopathy.
    Wimmer et al.
    Nature, 2019;565:505
  12. Isolation and in vitro expansion of human colonic stem cells.
    Jung et al.
    Nat.Med., 2011;17:1227
  13. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.
    Ishizaki et al.
    Mol.Pharmacol., 2000;57:976
  14. Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity.
    Santos et al.
    Nat.Commun., 2019;10:4407
  15. Direct conversion of normal and Alzheimer's Disease human fibroblasts into neuronal cells by small molecules.
    Hu et al.
    Cell Stem Cell, 2015;17:204

Product Datasheets

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Citations for Y-27632 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Y-27632 dihydrochloride include:

251 Citations: Showing 1 - 10

  1. An in vivo neuroimmune organoid model to study human microglia phenotypes.
    Authors: Schafer Et al.
    Cell  2023;186:2111
  2. An improved protocol for generation and characterization of human-induced pluripotent stem cell-derived retinal pigment epithelium cells
    Authors: Surendran Et al.
    STAR Protoc  2022;3:101803
  3. Pancreatic islet cryopreservation by vitrification achieves high viability, function, recovery and clinical scalability for transplantation.
    Authors: Zhan Et al.
    Nat.Med.  2022;28:798
  4. Biphasic activation of WNT signaling facilitates the derivation of midbrain dopamine neurons from hESCs for translational use.
    Authors: Kim Et al.
    Cell Stem Cell  2021;28:343
  5. Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01
    Authors: Piao Et al.
    Cell Stem Cell  2021;28:217
  6. Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation
    Authors: Leibel Et al.
    Curr Protoc Stem Cell Biol  2020;54:e118
  7. Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties.
    Authors: Panciera Et al.
    Nat Mater  2020;19:797
  8. Efficient Generation of Trunk Neural Crest and Sympathetic Neurons from Human Pluripotent Stem Cells Via a Neuromesodermal Axial Progenitor Intermediate.
    Authors: Frith and Tsakiridis
    Curr Protoc Stem Cell Biol  2019;:e81
  9. Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons.
    Authors: Rehbach Et al.
    Sci Rep  2019;9:9615
  10. User-defined morphogen patterning for directing human cell fate stratification.
    Authors: Regier Et al.
    Sci Rep  2019;9:6433
  11. Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells.
    Authors: Martin-Gallausiaux Et al.
    Front Immunol  2019;9:2838
  12. Esomeprazole Increases Airway Surface Liquid pH in Primary Cystic Fibrosis Epithelial Cells.
    Authors: Delpiano Et al.
    Front Pharmacol  2019;9:1462
  13. Quantification of human neuromuscular function through optogenetics.
    Authors: Vila Et al.
    Theranostics  2019;9:1232
  14. Automated real-time monitoring of human pluripotent stem cell aggregation in stirred tank reactors.
    Authors: Schwedhelm Et al.
    Sci Rep  2019;9:12297
  15. The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest.
    Authors: Duman Et al.
    Elife  2019;8:e47566
  16. Evaluating Shigella flexneri pathogenesis in the human enteroid model.
    Authors: Ranganathan Et al.
    Infect Immun  2019;87
  17. The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and MetF. cytotoxicity in breast cancer.
    Authors: Zhuang Et al.
    Cancer Metab  2019;7:1
  18. Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale.
    Authors: Wang Et al.
    PeerJ  2019;6:e6143
  19. Highly Efficient CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells.
    Authors: Maguire Et al.
    Curr Protoc Stem Cell Biol  2019;48:e64
  20. Protective effects of oxymatrine against DSS-induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathway.
    Authors: Wang Et al.
    Biosci Rep  2019;39
  21. Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate.
    Authors: Crowell Et al.
    Cell Rep  2019;28:1499
  22. Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development.
    Authors: Genga Et al.
    Cell Rep  2019;27:708
  23. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.
    Authors: Mair Et al.
    Cell Rep  2019;27:599
  24. An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons.
    Authors: Rhee Et al.
    Cell Rep  2019;27:2212
  25. A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons.
    Authors: Meijer Et al.
    Cell Rep  2019;27:2199
  26. Entosis Controls a Developmental Cell Clearance in C. elegans.
    Authors: Lee Et al.
    Cell Rep  2019;26:3212
  27. Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery.
    Authors: Larraufie Et al.
    Cell Rep  2019;26:1399
  28. A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability.
    Authors: Wilke Et al.
    Cell Host Microbe  2019;26:123
  29. Single-Cell Sequencing of iPSC-Da Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
    Authors: Lang Et al.
    Cell Stem Cell  2019;24:93
  30. Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells.
    Authors: Montel-Hagen Et al.
    Cell Stem Cell  2019;24:376
  31. Establishment of porcine and human expanded potential stem cells.
    Authors: Gao Et al.
    Nat Cell Biol  2019;21:687
  32. Nuclear envelope deformation controls cell cycle progression in response to mechanical force.
    Authors: Aureille Et al.
    EMBO Rep  2019;20:e48084
  33. Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells.
    Authors: Nguyen Et al.
    Stem Cells Int  2019;2019:3298432
  34. A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells.
    Authors: Chen Et al.
    Nat.Methods  2019;18:528
  35. Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment.
    Authors: Georgouli Et al.
    Cell  2019;176:757
  36. Identification of Kinases Responsible for p53-Dependent Autophagy.
    Authors: Celano Et al.
    iScience  2019;15:109
  37. FGF Modulates the Axial Identity of Trunk hPSC-Derived Neural Crest but Not the Cranial-Trunk Decision.
    Authors: Hackland Et al.
    Stem Cell Reports  2019;12:920
  38. Chemical conversion of human fetal astrocytes into neurons through modulation of multiple signaling pathways.
    Authors: Yin Et al.
    Stem Cell Reports  2019;12:488
  39. A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-β1 in Steroid-Resistant Airway Diseases.
    Authors: Li Et al.
    iScience  2019;12:232
  40. Exosomes regulate neurogenesis and circuit assembly.
    Authors: Sharma Et al.
    Proc Natl Acad Sci U S A  2019;116:16086
  41. Repurposed quinacrine synergizes with CIS. reducing the effective dose required for treatment of head and neck squamous cell carcinoma.
    Authors: Bryant Et al.
    Oncotarget  2019;10:5229
  42. Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14.
    Authors: Ervin Et al.
    Stem Cell Res Ther  2019;10:43
  43. Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction.
    Authors: Park Et al.
    Nat Commun  2019;10:3123
  44. Modulation of Wnt/BMP pathways during corneal differentiation of hPSC maintains ABCG2-positive LSC population that demonstrates increased regenerative potential.
    Authors: Vattulainen Et al.
    Stem Cell Res Ther  2019;10:236
  45. Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability.
    Authors: Hladik Et al.
    Stem Cell Res Ther  2019;10:218
  46. Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory.
    Authors: Bertero Et al.
    Nat Commun  2019;10:1538
  47. TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation.
    Authors: Ng-Blichfeldt Et al.
    Am J Physiol Lung Cell Mol Physiol  2019;
  48. Rho-Kinase Inhibition Ameliorates D.nib-Induced Endothelial Dysfunction and Pulmonary Hypertension.
    Authors: Fazakas Et al.
    Front Physiol  2018;9:537
  49. Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.
    Authors: Ackermann Et al.
    Nat Commun  2018;9:5088
  50. A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
    Authors: Sheng Et al.
    Nat Commun  2018;9:4047
  51. Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity.
    Authors: Hepburn Et al.
    Oncotarget  2018;9:23029
  52. Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity.
    Authors: McHugh Et al.
    Oncotarget  2018;9:20265
  53. Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids.
    Authors: Magro-Lopez Et al.
    Stem Cell Res.Ther.  2018;9:186
  54. Expansion of Airway Basal Cells and Generation of Polarized Epithelium.
    Authors: Levardon Et al.
    Bio Protoc  2018;8
  55. Generating Loss-of-function iPSC Lines with Combined CRISPR Indel Formation and Reprogramming from Human Fibroblasts.
    Authors: Tidball Et al.
    Bio Protoc  2018;8
  56. Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma.
    Authors: Pitha Et al.
    Transl Vis Sci Technol  2018;7:6
  57. Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth.
    Authors: Rath Et al.
    Cancer Res  2018;78:3321
  58. Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells.
    Authors: Ho Et al.
    Invest Ophthalmol Vis Sci  2018;59:1969
  59. Advanced maturation of human cardiac tissue grown from pluripotent stem cells.
    Authors: Ronaldson-Bouchard Et al.
    Nature  2018;556:239
  60. α-Tubulin Acetyltransferase Is a Novel Target Mediating Neurite Growth Inhibitory Effects of Chondroitin Sulfate Proteoglycans and Myelin-Associated Glycoprotein.
    Authors: Wong Et al.
    Eneuro  2018;5
  61. Impaired adhesion of induced pluripotent stem cell-derived cardiac progenitor cells (iPSC-CPCs) to isolated extracellular matrix from failing hearts.
    Authors: McKown Et al.
    Heliyon  2018;4:e00870
  62. A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.
    Authors: Ford Et al.
    Dev Cell  2018;47:509
  63. Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells.
    Authors: McCauley Et al.
    Curr Protoc Stem Cell Biol  2018;45:e51
  64. CRISPR/Cas9-based Targeted Genome Editing for the Development of Monogenic Diseases Models with Human Pluripotent Stem Cells.
    Authors: Gupta Et al.
    Curr Protoc Stem Cell Biol  2018;45:e50
  65. Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.
    Authors: Ng-Blichfeldt Et al.
    EBioMedicine  2018;36:461
  66. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.
    Authors: Schaffer Et al.
    Cell Rep  2018;25:2470
  67. Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation.
    Authors: Mehta Et al.
    Cell Rep  2018;25:1081
  68. Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease.
    Authors: Sommer Et al.
    Cell Stem Cell.  2018;23:123
  69. Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium.
    Authors: Lynch Et al.
    Cell Stem Cell  2018;22:653
  70. Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1.
    Authors: Pirie Et al.
    PLoS Genet  2018;14:e1007732
  71. Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses.
    Authors: Sima Et al.
    Orphanet J Rare Dis  2018;13:54
  72. Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity.
    Authors: Sharma Et al.
    Nat Protoc  2018;13:3018
  73. Neural stem cells for disease modeling and evaluation of therapeutics for Tay-Sachs disease.
    Authors: Vu Et al.
    Orphanet J Rare Dis  2018;13:152
  74. Human Induced Pluripotent Stem Cell Production and Expansion from Blood using a Non-Integrating Viral Reprogramming Vector.
    Authors: Sharma Et al.
    Curr Protoc Mol Biol  2018;122:e58
  75. Generation of functioning nephrons by implanting human pluripotent stem cell-derived kidney progenitors.
    Authors: Bantounas Et al.
    Stem Cell Reports  2018;10:766
  76. Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells.
    Authors: Medelnik Et al.
    Stem Cell Reports  2018;10:1751
  77. Differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules.
    Authors: Asumda Et al.
    Differentiation  2018;101:16
  78. ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.
    Authors: Rath Et al.
    EMBO Mol Med  2017;9:198
  79. Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.
    Authors: Sloan Et al.
    Neuron  2017;95:779
  80. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.
    Authors: Abud Et al.
    Neuron  2017;94:278
  81. Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors.
    Authors: Benedicto
    Nat Commun  2017;8:15374
  82. Dynamic behaviour of human neuroepithelial cells in the developing forebrain.
    Authors: Subramanian Et al.
    Nat Commun  2017;8:14167
  83. Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts.
    Authors: Bonan Et al.
    Oncotarget  2017;8:1304
  84. Atypical PKC and Notch Inhibition Differentially Modulate Cortical Interneuron Subclass Fate from Embryonic Stem Cells.
    Authors: Tischfield Et al.
    Stem Cell Reports  2017;8:1135
  85. Chemerin-induced arterial contraction is Gi- and calcium-dependent.
    Authors: Ferland Et al.
    Vascul Pharmacol  2017;88:30
  86. A pluripotent stem cell-based model for post-implantation human amniotic sac development.
    Authors: Shao
    Nat Commun  2017;8(1):208
  87. ASXL3 Is a Novel Pluripotency Factor in Human Respiratory Epithelial Cells and a Potential Therapeutic Target in Small Cell Lung Cancer.
    Authors: Shukla Et al.
    Cancer Res  2017;77:6267
  88. Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2).
    Authors: Kinarivala Et al.
    J Med Chem  2017;60:9739
  89. Derivation of telencephalic oligodendrocyte progenitors from human pluripotent stem cells.
    Authors: Major Et al.
    Curr Protoc Stem Cell Biol  2017;39:1H.10.1
  90. A modular platform for differentiation of human PSCs into all major ectodermal lineages.
    Authors: Tchieu Et al.
    Cell Stem Cell.  2017;31:399
  91. Single-cell gene expression analysis reveals regulators of distinct cell subpopulations among developing human neurons.
    Authors: Wang Et al.
    Genome Res  2017;27:1783
  92. Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts.
    Authors: Vermilyea Et al.
    Stem Cells Dev  2017;26:1225
  93. Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells.
    Authors: Kotton Et al.
    Cell Stem Cell.  2017;21:472
  94. Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations.
    Authors: Lee Et al.
    Cell Stem Cell  2017;21:179
  95. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling.
    Authors: McCauley Et al.
    Cell Stem Cell  2017;20:844
  96. Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia.
    Authors: Bershteyn Et al.
    Cell Stem Cell  2017;20:435
  97. Entosis Is Induced by Glucose Starvation.
    Authors: Hamann Et al.
    Cell Rep  2017;20:201
  98. In Vivo Human Somitogenesis Guides Somite Development from hPSCs.
    Authors: Xi
    Cell Rep  2017;18(6):1573
  99. Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock.
    Authors: Hubaud Et al.
    Cell  2017;171:668
  100. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
    Authors: Yang Et al.
    Cell  2017;169:243
  101. An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance.
    Authors: Mohapatra Et al.
    Development  2017;144:1072
  102. Mesoderm-specific Stat3 deletion affects expression of Sox9 yielding Sox9-dependent phenotypes.
    Authors: Hall
    PLoS Genet  2017;13(2):e1006610
  103. Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells.
    Authors: Morizane and Bonventre
    Nat Protoc  2017;12:195
  104. Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions.
    Authors: Bao Et al.
    Nat Protoc  2017;12:1890
  105. Neural stem cells for disease modeling of Wolman disease and evaluation of therapeutics.
    Authors: Aguisanda Et al.
    Orphanet J Rare Dis  2017;12:120
  106. The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress.
    Authors: Shi
    Mol Brain  2017;10(1):38
  107. The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ.
    Authors: Edwards Et al.
    Sci Signal  2017;10
  108. An in vitro model of murine middle ear epithelium.
    Authors: Mulay Et al.
    Dis Model Mech  2016;9:1405
  109. Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids
    Authors: Jardé Et al.
    Nature Communications  2016;7:13207
  110. Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6.
    Authors: Guye Et al.
    Sci Rep  2016;7:10243
  111. Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamics.
    Authors: Kellner Et al.
    Hippocampus  2016;6:816
  112. Risk of prenatal depression and stress treatment: alteration on serotonin system of offspring through exposure to Fluox..
    Authors: Pei Et al.
    Sci Rep  2016;6:33822
  113. DArgic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
    Authors: Borgs Et al.
    Scientific Reports  2016;6:33377
  114. Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction.
    Authors: Koopmans Et al.
    Sci Rep  2016;6:30676
  115. Tumor-induced remote ECM network orientation steers angiogenesis.
    Authors: Balcioglu Et al.
    Development  2016;6:22580
  116. Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A.
    Authors: Long Et al.
    Stem Cells Transl Med  2016;5:1644
  117. Local mechanical forces promote polarized junctional assembly and axis elongation in Drosophila.
    Authors: Yu and Fernandez-Gonzalez
    Elife  2016;5
  118. ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells.
    Authors: Rath Et al.
    Sci Data  2016;3:160101
  119. Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization.
    Authors: Hien Et al.
    J Biol Chem  2016;291:3552
  120. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
    Authors: Zeltner Et al.
    Nat Med  2016;22:1421
  121. Cryopreservation of Brain Endothelial Cells Derived from Human Induced Pluripotent Stem Cells Is Enhanced by Rho-Associated Coiled Coil-Containing Kinase Inhibition.
    Authors: Wilson Et al.
    Tissue Eng Part C Methods  2016;22:1085
  122. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell: Stem Cell  2016;19:217
  123. Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells.
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