xStAx-VHLL
Purity: ≥95%
Biological Activity
xStAx-VHLL is a selective peptide-based β-catenin Degrader (PROTAC®). Comprises a β-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces β-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades β-catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids.β-catenin antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF1329 and NBP1-54467.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Technical Data
(Modifications: Arg-1 = N-terminal Ac, X = (S)-2-(4-pentenyl)alanine, X-6 and X-10 stapled together with a double bond, Arg-17 = Arg-Ahx, Pro-24 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer.
Liao et al.
Cell Discov., 2020;6:35
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Peptide FAQsReviews for xStAx-VHLL
There are currently no reviews for this product. Be the first to review xStAx-VHLL and earn rewards!
Have you used xStAx-VHLL?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
