XL 413 hydrochloride

Catalog # Availability Size / Price Qty
5493/10
5493/50
XL 413 hydrochloride | CAS No. 1169562-71-3 | Other Kinase Inhibitors
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Description: Potent and selective Cdc7 inhibitor
Alternative Names: BMS 863233

Chemical Name: 8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride

Purity: ≥99%

Product Details
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Biological Activity

XL 413 hydrochloride is a potent and selective Cdc7 inhibitor (IC50 = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice. XL 413 also improves homology-directed repair (HDR) editing in hematopoietic stem cells (HSC).

Technical Data

M.Wt:
326.18
Formula:
C14H12ClN3O2.HCl
Solubility:
Soluble to 20 mM in water
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1169562-71-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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