WZB 117
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Description: GLUT inhibitor
Chemical Name: 3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate)
Purity: ≥98%
Biological Activity
WZB 117 is a GLUT inhibitor (Ki(app) values are 0.2, 10 and 10 μM for GLUT4, GLUT1 and GLUT3, respectively). Competitive inhibitor of net glucose uptake but a noncompetitive inhibitor of sugar efflux from cells. Inhibits passive sugar transport in human erythrocytes and cancer cell lines. Attenuates erythrocyte 3-O-methylglucose (3MG) uptake in vitro (Ki = 6 μM). Suppresses tumor growth in a nude mouse model.Technical Data
M.Wt:
368.31
Formula:
C20H13FO6
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1223397-11-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) inhibits GLUT1-mediated sugar transport by binding reversibly at the exofacial sugar binding site.
Ojelabi et al.
J.Biol.Chem., 2016;291:26762 -
Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells.
Koch et al.
Oncotarget, 2015;6:32748
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