WAY 100635 maleate
Chemical Name: N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate
Purity: ≥99%
Biological Activity
WAY 100635 maleate is a potent, silent antagonist of 5-HT1A receptors (IC50 = 2.2 nM; Ki = 0.84 nM for rat 5-HT1A receptors). Displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes. Also exhibits agonist activity at dopamine D4 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635.
Mensonides-Harsema et al.
J.Med.Chem., 2000;43:432 -
Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2''-pyridinyl)-p-iodobenzamido]ethyl]piperazine (p-MPPI): a new iodinated 5-HT1A ligand.
Zhuang et al.
J.Med.Chem., 1994;37:1406 -
A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635.
Forster et al.
Eur.J.Pharmacol., 1995;281:81 -
WAY-100635 is a potent DA D4 receptor agonist.
Chemel et al.
Psychopharmacology (Berl)., 2006;188:244
Product Datasheets
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Citations for WAY 100635 maleate
The citations listed below are publications that use Tocris products. Selected citations for WAY 100635 maleate include:
13 Citations: Showing 1 - 10
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Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons.
Authors: Khaled Et al.
Elife 2020;9
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Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT1A Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile.
Authors: Anna Et al.
J Med Chem 2020;63:10946-10971
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Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.
Authors: Nguyen Et al.
Korean J Physiol Pharmacol 2019;23:271
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A neural circuit for comorbid depressive symptoms in chronic pain.
Authors: Zhou Et al.
Nat Neurosci 2019;22:1649
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Serotonin receptor oligomerization regulates cAMP-based signaling.
Authors: Sonal Et al.
J Cell Sci 2019;132
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A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory.
Authors: Andrew Et al.
Neuron 2019;103:489-505.e7
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Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands.
Authors: Walory Et al.
Int J Mol Sci 2018;19
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Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
Authors: Rodríguez-Muñoz Et al.
Mol Brain 2018;11:51
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Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron.
Authors: Yin Et al.
Cereb Cortex 2017;27:509
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Brain serotoninergic nervous system is involved in bombesin-induced frequent urination through brain 5-HT7 receptors in rats.
Authors: Shimizu Et al.
Br J Pharmacol 2017;174:3072
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The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies.
Authors: Wierońska Et al.
Sci Transl Med 2015;232:259
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5-HT(1A)-like receptor activation inhibits abstinence-induced metha. withdrawal in planarians.
Authors: Rawls Et al.
Neurosci Lett 2010;484:113
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Vascular endothelial growth factor signaling is required for the behavioral actions of antidepressant treatment: pharmacological and cellular characterization.
Authors: Greene Et al.
Neuropsychopharmacology 2009;34:2459
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