ω-Conotoxin GVIA

Catalog # Availability Size / Price Qty
1085/250U
ω-Conotoxin GVIA
1 Image
Description: CaV2.2 blocker

Purity: ≥95%

Product Details
Citations (15)
Reviews

Biological Activity

ω-Conotoxin GVIA is a peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG (Cat. No. 0342)-induced long term depression in vivo.

Technical Data

M.Wt:
3037
Formula:
C120H182N38O43S6
Sequence:
CKSXGSSCSXTSYNCCRSCNXYTKRCY

(Modifications: X = Hyp, Disulfide bridges: 1-16, 8-19, 15-26, Tyr-27 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
106375-28-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Butanol isomers exert distinct effects on voltage-gated calcium channel currents and thus catecholamine secretion in adrenal chromaffin cells.
    McDavid, Sarah, Bauer, Mary Bet, Brindley, Rebecca, Jewell, Mark L, Currie, Kevin P
    PLoS ONE, 2014;9(10):e109203.
  2. Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth.
    Mire E, Mezzera C, Leyva-Diaz E, Paternain AV, Squarzoni P, Bluy L, Castillo-Paterna M, Lopez MJ, Peregrin S, Tessier-Lavigne M, Garel S, Galceran J, Lerma J, Lopez-Bendito G
    Nat. Neurosci., 2012;15(8):1134-43.
  3. Distinct Calcium Sources Support Multiple Modes of Synaptic Release from Cranial Sensory Afferents

    J Neurosci, 2016;36(34):8957-66.
  4. Distinct mechanisms contribute to agonist and synaptically induced metabotropic glutamate receptor long-term depression.
    Connelly et al.
    Eur.J.Pharmacol., 2011;667:160
  5. Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels.
    Sato et al.
    Biochem.Biophys.Res.Comm., 1993;194:1292
  6. Multiple types of neuronal calcium channels and their selective modulation.
    Tsien et al.
    TiNS, 1988;11:431
  7. Prolonged cardiovascular effects of the N-type Ca2+ channel antagonist ω-conotoxin GVIA in conscious rabbits.
    Wright and Angu
    J.Cardiovasc.Pharmacol., 1997;30:392

Product Datasheets

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Citations for ω-Conotoxin GVIA

The citations listed below are publications that use Tocris products. Selected citations for ω-Conotoxin GVIA include:

15 Citations: Showing 1 - 10

  1. Molecular basis of ancestral vertebrate electroreception.
    Authors: Bellono
    Nature  2017;543:391
  2. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.
    Authors: Cassilly Et al.
    Front Cell Neurosci  2016;11:e0154932
  3. Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice.
    Authors: Perissinotti Et al.
    Proc Natl Acad Sci U S A  2015;8:444
  4. σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.
    Authors: Pan Et al.
    Addict Biol  2014;350:290
  5. Presynaptic calcium channel inhibition underlies CB1� cannabinoid receptor-mediated suppression of GABA release.
    Authors: Szabó Et al.
    PLoS One  2014;34:7958
  6. Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
    Authors: Mahler Et al.
    J Neurosci  2014;19:49
  7. Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels.
    Authors: Schuwald Et al.
    J Neurosci  2013;8:e59998
  8. Comparative functional expression of nAChR subtypes in rodent DRG neurons.
    Authors: Smith Et al.
    Front Cell Neurosci  2013;7:225
  9. Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.
    Authors: Medrihan Et al.
    Nature  2013;4:1512
  10. Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice.
    Authors: Izzo Et al.
    Br J Pharmacol  2012;166:1444

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