Home / Complement Signaling inhibitors / W 54011

W 54011

Catalog #: 5455
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5455/10
5455/50
W 54011 | CAS No. 405098-33-1 | Complement Signaling inhibitors
1 Image
Description: High affinity C5a receptor antagonist

Chemical Name: N-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity

W 54011 is a high affinity C5a receptor antagonist (Ki = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).

Technical Data

M.Wt:
493.08
Formula:
C30H36N2O2.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
405098-33-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of a potent and orally active non-peptide C5a receptor antagonist.
    Sumichika et al.
    J.Biol.Chem., 2002;277:49403
  2. Function, structure and therapeutic potential of complement C5a receptors.
    Monk et al.
    Br.J.Pharmacol., 2007;152:429
  3. Autocrine effects of tumor-derived complement.
    Cho et al.
    Cell Rep., 2014;6:1085

Product Datasheets

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Citations for W 54011

The citations listed below are publications that use Tocris products. Selected citations for W 54011 include:

2 Citations: Showing 1 - 2

  1. Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors.
    Authors: Trent M Et al.
    Mol Cell  2021;81:4605-4621.e11
  2. Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21.
    Authors: Sahu Et al.
    Cell Rep  2019;28:2567

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