Vincristine sulfate
Chemical Name: 22-Oxovincaleukoblastine
Purity: ≥95%
Biological Activity
Vincristine sulfate is a anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition.
Goldman A, Majumder B, Dhawan A, Ravi S, Goldman D, Kohandel M, Majumder P, Sengupta S
Nat Commun, 2015;6(0):6139. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro.
Jordan et al.
Cancer Res., 1985;45:2741 -
Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate.
Takano et al.
Pathol.Res.Pract., 1993;189:197 -
The effect of antimicrotubule agents on signal transduction pathways of apoptosis.
Wang et al.
Cancer Chemother.Pharmacol., 1999;44:355
Product Datasheets
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Citations for Vincristine sulfate
The citations listed below are publications that use Tocris products. Selected citations for Vincristine sulfate include:
9 Citations: Showing 1 - 9
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Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer.
Authors: Mabe Et al.
J Clin Invest 2018;128:4413
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The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
Authors: Zhang
Mol Cancer Ther 2017;16(6):1021
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Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells.
Authors: Torres Et al.
Oncotarget 2016;7:67373
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MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM.
Authors: Stojcheva Et al.
Oncotarget 2016;7:12937
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Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition.
Authors: Goldman Et al.
Nat Commun 2015;6:6139
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The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study.
Authors: Kathawala Et al.
Oncotarget 2015;6:510
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Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas.
Authors: Knutson Et al.
PLoS One 2014;9:e111840
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Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated PacT. resistance: a preclinical study.
Authors: Kathawala Et al.
Mol Cancer Ther 2014;13:714
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Synergistic effects of oncolytic reovirus and doce. chemotherapy in prostate cancer.
Authors: Heinemann Et al.
Sci Rep 2011;11:221
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