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Venlafaxine hydrochloride

Catalog #: 2917
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2917/10
2917/50
Venlafaxine hydrochloride | CAS No. 99300-78-4 | 5-HT Transporter Inhibitors
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Description: 5-HT and NA reuptake inhibitor (SNRI)
Alternative Names: Wy 45030

Chemical Name: 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity

Venlafaxine hydrochloride is a dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (Ki values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats.

Technical Data

M.Wt:
313.86
Formula:
C17H27NO2.HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
99300-78-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Venlafaxine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Venlafaxine hydrochloride include:

3 Citations: Showing 1 - 3

  1. Distinct Neuropsychological Mechanisms May Explain Delayed- Versus Rapid-Onset Antidepressant Efficacy.
    Authors: Stuart Et al.
    Proc Natl Acad Sci U S A  2015;40:2165
  2. Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons.
    Authors: Yuen Et al.
    J Biol Chem  2014;289:25177
  3. A translational rodent assay of affective biases in depression and antidepressant therapy.
    Authors: Stuart Et al.
    Neuropsychopharmacology  2013;38:1625

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