Valsartan
Chemical Name: (S)-3-methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)pentanamido]butanoic acid
Purity: ≥99%
Biological Activity
Valsartan is a high affinity AT1 receptor antagonist (Ki = 2.38 nM). Displays 30,000-fold selectivity over AT2 receptors. Inhibits angiotensin II-induced release of aldosterone in vitro. Orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype.
Criscione et al.
Br.J.Pharmacol., 1993;110:761 -
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Wexler et al.
J.Med.Chem., 1996;39:625 -
Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers.
Hanafy et al.
Br.J.Pharmacol., 2008;153:90
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