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UC 112

Catalog #: 5251
1 Citation Datasheet / COA / SDS

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UC 112 | CAS No. 383392-66-3 | Apoptosis Inducer Compounds
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Description: IAP and XIAP inhibitor; antitumor

Chemical Name: 5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

UC 112 is an iAP inhibitor (IC50 values from 0.7 - 3.4 μM); inhibits cell growth in multiple cancer cell lines and in a melanoma xenograft model in vivo. Also suppresses X-linked inhibitor of apoptosis protein (XIAP) and survivin levels. Inhibits the growth of P-glycoproteins and activates caspase-3/7 and caspase-9.

Technical Data

M.Wt:
348.44
Formula:
C22H24N2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
383392-66-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for UC 112

The citations listed below are publications that use Tocris products. Selected citations for UC 112 include:

1 Citation: Showing 1 - 1

  1. A toolbox for the generation of chemical probes for baculovirus IAP repeat containing proteins
    Authors: Schwalm Et al.
    Front.Cell.Dev.Biol.  2022;10:886537

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