(-)-U-50488 hydrochloride
Chemical Name: trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Purity: ≥99%
Biological Activity
(-)-U-50488 hydrochloride is a more active enantiomer of (±)-U-50488.Racemate and (+)-enantiomer also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist.
De Costa et al.
FEBS Lett., 1987;223:335 -
Withdrawal contractures of guinea-pig isolated ileum after acute activation of κ opioid receptors.
Morrone et al.
Br.J.Pharmacol., 1993;109:48 -
Effect of chronic administration of U-50,488H, a kappa opioid receptor agonist on central DA (D2) receptors of the rat.
Reddy and Bhargava
Eur.J.Pharmacol., 1993;235:23 -
Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in chinese hamster ovary cells.
Zhu et al.
J.Pharmacol.Exp.Ther., 1998;285:28
Product Datasheets
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Citation for (-)-U-50488 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for (-)-U-50488 hydrochloride include:
1 Citation: Showing 1 - 1
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Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis
Authors: Pirino Et al.
Neuropharmacology 2020;181:108341
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We have used this product numerous times in animal behavior studies and with consistent results.
