Tranilast

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo.
   Isaji et al.
   Br.J.Pharmacol., 1997;122:1061
3. Tranilast restores cytokine-induced nitric oxide production against platelet derived growth factor in vascular smooth muscle cells.
   Hishikawa et al.
   J.Cardiovasc.Pharmacol., 1996;28:200
4. Regulation of calcium-permeable TRPV2 channel by Ins in pancreatic beta-cells.
   Hisanaga et al.
   Diabetes., 2009;58:174
5. Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II.
   Jin et al.
   Eur.J.Pharmacol., 1998;361:199
6. Tranilast binds to Aβ monomers and promotes Aβ fibrillation.
   Connors et al.
   Biochemistry, 2013;

Product Datasheets