Tolvaptan

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. 7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoyl-amino)benzoyl ]-2,3,4,5-tetrahydro-1H-1-benzazepine (OPC-41061): a potent, orally active nonpeptide arginine vasopressin V₂ receptor antagonist.
   Kondo et al.
   Bioorg.Med.Chem., 1999;7:1743
2. Tolvaptan.
   Ghali et al.
   Nat.Rev.Drug Discov., 2009;8:611
3. Tolvaptan delays the onset of end-stage renal disease in a polycystic kidney disease model by suppressing increases in kidney volume and renal injury.
   Aihara et al.
   J.Pharmacol.Exp.Ther., 2014;349:258
4. Chronic administration of oral vasopressin type 2 receptor antagonist tolv. exerts both myocardial and renal protective effects in rats with hypertensive heart failure.
   Morooka et al.
   Circ.Heart.Fail., 2012;5:484

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