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TM2 TEAD inhibitor

Catalog #: 7917 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7917/10
7917/50
TM2 TEAD inhibitor | CAS No. 1008768-41-9 | YAP1
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Description: Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling

Chemical Name: 4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide

Purity: ≥98%

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Biological Activity

TM2 TEAD inhibitor is a potent and reversible TEA domain transcription factor inhibitor (IC50 = 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively). It inhibits TEAD-YAP association and transcriptional activity. TM2 TEAD inhibitor exhibits strong antiproliferation effects as a single agent or in combination with a MEK inhibitor in YAP-dependent cancer cells. Also inhibits YAP-dependent liver organoid growth ex vivo.

Technical Data

M.Wt:
435.57
Formula:
C26H33N3O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1008768-41-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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