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TFC 007

Catalog #: 5108 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5108/10
5108/50
TFC 007 | CAS No. 927878-49-7 | Synthase/Synthetase Inhibitors
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Description: Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor

Chemical Name: N-[4-[4-(4-Morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide

Purity: ≥98%

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Biological Activity

TFC 007 is a potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor (IC50 = 83 nM). Inhibits PGD2 production and late phase nasal blockage in an animal model of allergic rhinitis. Exhibits negligible effects on COX-1, COX-2, 5-LOX, LTC4 synthase, TXA2 synthase and microsomal prostaglandin E2 synthase.

Technical Data

M.Wt:
487.55
Formula:
C27H29N5O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
927878-49-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs.
    Nabe et al.
    Prostaglandins Other Lipid Mediat., 2011;95:27

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