Tesaglitazar

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Structure of the PPARβ and -γ ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family.
   Cronet et al.
   Structure, 2001;9:699
2. AZ 242, a novel PPARα/γ agonist with beneficial effects on Ins resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats.
   Ljung et al.
   J.Lipid Res., 2002;43:1855
3. Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor α/γ agonist ragaglitazar.
   Ebdrup et al.
   J.Med.Chem., 2003;46:1306
4. The dual PPARα/γ agonist tesaglitazar blocks progression of pre-existing atherosclerosis in APOE*3Leiden.CETP transgenic mice.
   van der Hoorn et al.
   Br.J.Pharmacol., 2009;156:1067

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