Home / Adenylyl Cyclase Inhibitors / TDI 11861

TDI 11861

Catalog #: 8036 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8036/5
TDI 11861 | CAS No. 2857049-72-8 | Adenylyl Cyclase Inhibitors
1 Image
Description: Soluble adenylyl cyclase inhibitor

Chemical Name: (3R)-4-[2-[2-[[3-(2-Amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-3-morpholinemethanol

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

TDI 11861 is a potent and selective soluble adenylyl cyclase (sAC) inhibitor (IC50 values are 3.3 nM and 5.5 nM in biochemical and cellular assays, respectively; Kd = 1.4 nM). Inhibits cellular sAC-specific cAMP accumulation (IC50 = 7 nM) and blocks sperm capacitation in vitro. Cell permeable, not cytotoxic and suitable for both in vivo and in vitro use.

Technical Data

M.Wt:
494.93
Formula:
C22H25ClF2N6O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2857049-72-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Cornell University

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for TDI 11861

There are currently no reviews for this product. Be the first to review TDI 11861 and earn rewards!

Have you used TDI 11861?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.