TCS 2314

Catalog #: 3900 Datasheet / COA / SDS

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TCS 2314 | CAS No. 317353-73-4 | Integrin Receptor Inhibitors

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Description: α4β1 (VLA-4) antagonist

Chemical Name: 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid

Purity: ≥98%

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Biological Activity

TCS 2314 is an integrin very late antigen-4 (VLA-4; α₄β₁) antagonist (IC₅₀ = 4.4 nM). Blocks the activation of inflammatory cells.

Technical Data

M.Wt:

522.59

Formula:

C₂₈H₃₄N₄O₆

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

≥98%

Storage:

Store at RT

CAS No:

317353-73-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist.
Muro et al.
J.Med.Chem., 2009;52:7974

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