Sumanirole maleate

Catalog # Availability Size / Price Qty
2773/10
2773/50
Sumanirole maleate | CAS No. 179386-44-8 | Dopamine D2 Receptor Agonists
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Description: Selective D2 agonist

Chemical Name: (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-butenedioate

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity

Sumanirole maleate is a high affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Originally reported to exhibit >200-fold selectivity for the D2 receptor versus other dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively). More recently reported to be around 32-fold selective for D2 over D3 receptors (Ki values are 17.1 and 546 nM respectively). Exhibits antiParkinsonian activity.

Technical Data

M.Wt:
319.31
Formula:
C11H13N3O.C4H4O4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
179386-44-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

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Citations for Sumanirole maleate

The citations listed below are publications that use Tocris products. Selected citations for Sumanirole maleate include:

2 Citations: Showing 1 - 2

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