Sumanirole maleate
Chemical Name: (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-butenedioate
Purity: ≥98%
Biological Activity
Sumanirole maleate is a high affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Originally reported to exhibit >200-fold selectivity for the D2 receptor versus other dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively). More recently reported to be around 32-fold selective for D2 over D3 receptors (Ki values are 17.1 and 546 nM respectively). Exhibits antiParkinsonian activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Novel analogues of (R)-5-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) provide clues to DA D2/D3 receptor agonist selectivity.
Zou et al.
J.Med.Chem., 2016;59:2973 -
Sumanirole, a highly DA D2-selective receptor agonist: in vitro and in vivo pharmacological characterization and efficacy in animal models of Parkinson's disease.
McCall et al.
J.Pharmacol.Exp.Ther., 2005;314:1248 -
The effects of a selective DA D2 receptor agonist on behavioral and pathological outcome in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated squirrel monkeys.
Stephenson et al.
J.Pharmacol.Exp.Ther., 2005;314:1257
Product Datasheets
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Citations for Sumanirole maleate
The citations listed below are publications that use Tocris products. Selected citations for Sumanirole maleate include:
2 Citations: Showing 1 - 2
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Chemokine CXCL1 is responsible for cocaine-induced reward in mice.
Authors: Saika
NeurosciPharm Reports 2018;38(3):145
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Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
Authors: Chai Et al.
Neuron 2017;95:531
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