SSR 149415
Chemical Name: (2S,4R)-1-[(3R)-5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-(2-methoxyphenyl)-2-oxo-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide
Purity: ≥98%
Biological Activity
SSR 149415 is a potent and selective vasopressin V1B antagonist (Ki values are 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively). Displays >70-fold selectively for rat V1B over V1A, V2 oxytoxin and a range of other receptors and ion channels. Inhibits AVP-induced glucagon release in In-R1-G9 α-pancreatic cells in vitro. Inhibits stress-induced ACTH release and exhibits anxiolytic-like effects in anxiety models. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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An overview of SSR149415, a selective nonpeptide vasopressin V1b receptor antagonist for the treatment of stress-related disorders.
Serradeil-Le Gal et al.
CNS Drug Rev., 2005;11:53
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Citations for SSR 149415
The citations listed below are publications that use Tocris products. Selected citations for SSR 149415 include:
2 Citations: Showing 1 - 2
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Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury.
Authors: Mengliang Et al.
Elife 2021;10
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Arginine Vasopressin Modulates Ion and Acid/Base Balance by Regulating Cell Numbers of Sodium Chloride Cotransporter and H+-ATPase Rich Ionocytes.
Authors: Pung-Pung Et al.
Int J Mol Sci 2020;21
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