Home / NK3 Receptor Antagonists / SSR 146977 hydrochloride

SSR 146977 hydrochloride

Catalog #: 3297 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3297/10
3297/50
SSR 146977 hydrochloride | CAS No. 264618-38-4 | NK3 Receptor Antagonists
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Description: Potent and selective NK3 antagonist

Chemical Name: N1-[1-3-[(3R)-1-Benzoyl-3-(3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-piperidinyl]-N,N-dimethylurea hydrochloride

Purity: ≥98%

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Biological Activity

SSR 146977 hydrochloride is a potent and selective NK3 receptor antagonist (Ki values are 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor respectively). Also inhibits senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC50 = 10 nM).

Technical Data

M.Wt:
658.11
Formula:
C35H42Cl2N4O2.HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
264618-38-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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