Spexin

Catalog #: 6090 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
6090/1

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Description: Potent GAL2/3 agonist; exhibits anxiolytic effects in vivo

Alternative Names: NPQ,Neuropeptide Q

Purity: ≥95%

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Biological Activity

Spexin is a potent galanin receptor 2/3 (GAL₂/GAL₃) agonist (EC₅₀ values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. Attenuates LH secretion in goldfish. Exhibits anxiolytic effects in vivo.

Technical Data

M.Wt:

1619.9

Formula:

C₇₄H₁₁₄N₂₀O₁₉S

Sequence:

NWTPQAMLYLKGAQ

(Modifications: Gln-14 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

1370290-58-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity
Walewski et al.
Obesity (Silver Spring), 2014;22:1643
Development of spexin-based human galanin receptor type II-specific agonists with increased stability in serum and anxiolytic effect in mice.
Reyes-Alcaraz et al.
Sci.Rep., 2016;6:21453
Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.
Kim et al.
Endocrinology, 2014;155:1864

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