SLM 6031434 hydrochloride

Catalog # Availability Size / Price Qty
6281/50
6281/10
SLM 6031434 hydrochloride | CAS No. 1897379-34-8 | Sphingosine Kinase Inhibitors
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Description: Selective sphingosine kinase 2 (Sphk2) inhibitor

Chemical Name: (2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide hydrochloride

Purity: ≥98%

Product Details
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Biological Activity

SLM 6031434 hydrochloride is a Sphk2 inhibitor (Ki = 0.4 μM for mouse Sphk2). Exhibits 40-fold selectivity for Sphk2 over Sphk1. Decreases levels of sphingosine-1-phosphate (S1P) in U937 cells in vitro and increases blood levels of S1P in wild-type mice.

Technical Data

M.Wt:
489.96
Formula:
C22H30F3N5O2.HCl
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1897379-34-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of the University of Virginia Patent Foundation

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