Home / TRPC Channel Blockers / SKF 96365 hydrochloride

SKF 96365 hydrochloride

Catalog #: 1147
14 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1147/10
1147/50
SKF 96365 hydrochloride | CAS No. 130495-35-1 | TRPC Channel Blockers
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Description: TRPC channel inhibitor; also inhibits store-operated Ca2+ entry

Chemical Name: 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl-1H-imidazole hydrochloride

Purity: ≥99%

Product Details
Citations (14)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SKF 96365 hydrochloride is a store-operated Ca2+ entry (SOCE) inhibitor that inhibits STIM1. Also blocks TRPC channels, voltage-gated Ca2+ channels and potassium channels.

Technical Data

M.Wt:
402.92
Formula:
C22H26N2O3.HCl
Solubility:
Soluble to 20 mM in water with gentle warming
Purity:
≥99%
Storage:
Store at RT
CAS No:
130495-35-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes

    J Biol Chem, 2016;0(0):.
  2. Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation.
    Morimoto, Kazushi, Shirata, Naritosh, Taketomi, Yoshitak, Tsuchiya, Soken, Segi-Nishida, Eri, Inazumi, Tomoaki, Kabashima, Kenji, Tanaka, Satoshi, Murakami, Makoto, Narumiya, Shuh, Sugimoto, Yukihiko
    J Immunol, 2014;192(3):1130-7.
  3. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  4. The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries.
    Lim M, Choi SK, Cho YE
    PLoS ONE, 2012;7(4):e35177.
  5. STIM and Orai: the long-awaited constituents of store-operated calcium entry.
    Varnai et al.
    TiPS, 2009;30:118
  6. The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels.
    Singh et al.
    Br.J.Pharmacol., 2010;160:1464
  7. SK&F96365, a novel inhibitor of receptor-mediated calcium entry.
    Merritt et al.
    Biochem.J., 1990;271:515

Product Datasheets

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Citations for SKF 96365 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SKF 96365 hydrochloride include:

14 Citations: Showing 1 - 10

  1. Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21.
    Authors: Sahu Et al.
    Cell Rep  2019;28:2567
  2. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One  2014;9:e106316
  3. Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors.
    Authors: Alkhani Et al.
    Proc Natl Acad Sci U S A  2014;10:43
  4. Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells.
    Authors: Soltoff and Lannon
    PLoS One  2013;8:e72881
  5. Calcium release-dependent actin flow in the leading process mediates axophilic migration.
    Authors: Hutchins Et al.
    Biochem J  2013;33:11361
  6. Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity.
    Authors: Ben-Mabrouk and Tryba
    Mol Pain  2010;31:1219
  7. Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism.
    Authors: Fu and Pol
    J Neurosci  2010;30:10205
  8. Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.
    Authors: Kyriazis Et al.
    J Biol Chem  2010;285:6811
  9. Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels.
    Authors: Szikra Et al.
    PLoS One  2009;4:e6723
  10. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.
    Authors: Hildebrand Et al.
    J Neurosci  2009;29:9668

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