SKF 83822 hydrobromide

Catalog #: 2075
3 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
2075/10
2075/50

SKF 83822 hydrobromide | CAS No. 74115-10-9 | Dopamine D1 and D5 Receptor Agonists

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Description: Selective D1-like agonist

Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide

Purity: ≥98%

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Product Details

Citations (3)

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Biological Activity

SKF 83822 hydrobromide is a high affinity, selective dopamine D₁-like receptor agonist. K_i values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D₁, D₅, D₂, D₃, D₄, 5-HT_2A, α_1A and α_1B receptors respectively. Stimulates adenylyl cyclase (EC₅₀ = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.

Technical Data

M.Wt:

424.76

Formula:

C₂₀H₂₂ClNO₂.HBr

Solubility:

Soluble to 10 mM in ethanol and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at RT

CAS No:

74115-10-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Evidence for a distinct D₁-like DA receptor that couples to activation of phosphoinositide metabolism in brain.
Undie et al.
J.Neurochem., 1994;62:2045
Aberrant behavioural effects of a DA D1 receptor antagonist and agonist in monkeys: evidence of uncharted DA D1 receptor actions.
Peacock and Gerlach
Biol.Psychiatry, 2001;50:501
SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled D1-like receptors: behavioural topography.
O'Sullivan et al.
Eur.J.Pharmacol., 2004;486:273

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for SKF 83822 hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for SKF 83822 hydrobromide include:

3 Citations: Showing 1 - 3

DA in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory.
Authors: Kramar Et al.
J Neurosci 2014;39:1645
Ketogenic diet improves core symptoms of autism in BTBR mice.
Authors: Ruskin Et al.
PLoS One 2013;8:e65021
CODA-RET reveals functional selectivity as a result of GPCR heteromerization.
Authors: Urizar Et al.
Neuropsychopharmacology 2011;7:624

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