SJFα

Catalog # Availability Size / Price Qty
7268/5
SJFα | CAS No. 2254609-27-1 | Active Degraders
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Description: Potent and selective p38α PROTAC®
Alternative Names: SJFa PROTAC,SJFalpha PROTAC,SJFα PROTAC

Chemical Name: N-(3-Fluoro-4-((7-(4-(4-(2-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)butoxy)butoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Purity: ≥98%

Product Details
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Biological Activity

SJFα is a potent and selective p38α PROTAC® Degrader (DC50 = 7.16 nM; Dmax = 97.4%). SJFα comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Displays significantly lower potency degradation at p38δ (DC50 = 299 nM). Exhibits no significant degradation of p38β, p38γ or related MAPKs, ERK1/2, or JNK1/2.

p38γ antibodies validated for Simple Western™ (automated Western) instruments also available: Catalog # AF1347 and MAB1347.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
1120.28
Formula:
C59H67F2N7O11S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2254609-27-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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