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SJF 1521

Catalog #: 7261 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7261/5
SJF 1521 | CAS No. 2230821-40-4 | Active Degraders
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Description: Selective EGFR PROTAC®

Chemical Name: (2S,4R)-1-((S)-2-(tert-Butyl)-14-(4-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity: ≥98%

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Biological Activity

SJF 1521 is a selective EGFR PROTAC® Degrader. SJF 1521 comprises the EGFR inhibitor lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Exhibits selectivity for EGFR, including mutant forms, over HER2. Induces degradation of EGFR in OVCAR8 cells.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
1074.66
Formula:
C57H61ClFN7O9S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2230821-40-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The advantages of targeted protein degradation over inhibition: an RTK case study.
    Burslem et al.
    Cell Chem.Biol., 2018;25:67

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