Simple Plex Control for Human CD40/TNFRSF5

Simple Plex Control for Human CD40/TNFRSF5 Summary

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Background: CD40/TNFRSF5

CD40, also known as TNFRSF5, is a transmembrane TNF superfamily receptor that is expressed on the surface of B cells, dendritic cells, macrophages, monocytes and platelets, as well as endothelial and epithelial cells. Interaction of CD40 with CD40 Ligand leads to the aggregation of CD40 molecules resulting in the initiation of bidirectional intracellular signaling in both CD40 and CD40 Ligand expressing cells. This interaction promotes B cell activation and T cell-dependent humoral responses. CD40 serves multiple functions in both hematopoietic and epithelial cancers and is a target for tumor immunotherapy. Dysregulation of CD40/CD40 Ligand expression and interactions contributes to disease severity in AIDS, atherosclerosis, atherothrombosis, and restenosis.

Related Research Areas

• B Cell Activation
• B Cell Markers
• Co-stimulatory and Co-inhibitory Molecules
• Co-stimulatory Molecules Associated with Tfh Cells
• Cytokine and Growth Factor Receptors on VSMC
• Dendritic Cell Co-stimulatory Molecules
• Dendritic Cell Development
• gamma delta T Cells
• Immune Regulatory Molecules on Endothelial Cells
• MDSC Phenotyping - Negative Markers
• Microglia Activation
• Microglia Activation Markers
• Multiple Myeloma
• Regulation of B Cell Activation and Homeostasis by TNF Superfamily Members
• Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members
• Regulation of T Cell Co-stimulation by TNF Superfamily Members
• Regulatory T Cells (Tregs)
• Search Immune Checkpoint Targets
• TNF Superfamily
• TNF Superfamily Receptors
• Uptake of Amyloid beta by Glia Cells
• Uptake of Amyloid beta by Macrophages