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SIB 1508Y maleate

Catalog #: 4766 Datasheet / COA / SDS

Discontinued Product

4766 has been discontinued.
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SIB 1508Y maleate | CAS No. 192231-16-6 | Additional Nicotinic Receptor Agonists
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Description: Potent agonist of α4β2, α2β4, α4β4 and α3β4 nACh receptors

Chemical Name: 3-Ethynyl-5-[(2S)-1-methyl-2-pyrrolidinyl]pyridine maleate salt

Purity: ≥98%

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Biological Activity

SIB 1508Y maleate is a potent neuronal nicotinic ACh receptor agonist (EC50 values are 1.8, 5, 9 and 23 nM for α4β2, α2β4, α4β4 and α3β4 receptors respectively). Improves cognitive function in a MPTP-induced model of Parkinson's Disease in vivo.

Technical Data

M.Wt:
302.33
Formula:
C12H14N2.C4H4O4
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
192231-16-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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