SF 11

Catalog #: 3898
1 Citation Datasheet / COA / SDS

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3898/10
3898/50

SF 11 | CAS No. 443292-81-7 | NPY Receptor Antagonists

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Description: NPY Y2 receptor antagonist

Chemical Name: N-(4-Ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide

Purity: ≥99%

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Product Details

Citations (1)

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Biological Activity

SF 11 is an NPY Y₂ antagonist (IC₅₀ = 199 nM). Displays no affinity for Y₁ receptor at concentrations up to 35 μM. Causes significant lethality in mice. Displays antidepressant effects in rats. Brain penetrant.

Technical Data

M.Wt:

446.6

Formula:

C₂₇H₃₀N₂O₂S

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

≥99%

Storage:

Store at +4°C

CAS No:

443292-81-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Cardiovascular responses to chemical stimulation of the hypothalamic arcuate nucleus in the rat: role of the hypothalamic paraventricular nucleus.
Kawabe, Tetsuya, Kawabe, Kazumi, Sapru, Hreday N
PLoS ONE, 2012;7(9):e45180.
Characterization of the brain penetrant neuropeptide Y Y₂ receptor antagonist SF-11.
Domin et al.
ACS Chem.Neurosci., 2019;10:3454
Selective and brain penetrant neuropeptide Y Y₂ receptor antagonists discovered by whole-cell high-throughput screening.
Brothers et al.
Mol.Pharmacol., 2010;77:46

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Citation for SF 11

The citations listed below are publications that use Tocris products. Selected citations for SF 11 include:

1 Citation: Showing 1 - 1

Characterization of the brain penetrant neuropeptide Y Y₂ receptor antagonist SF-11.
Authors: Domin Et al.
ACS Chem Neurosci 2019;10:3454

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