SCH 51344
Chemical Name: 2-[2-[(6-Methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol
Purity: ≥99%
Biological Activity
SCH 51344 is a potent MTH1 inhibitor (Kd = 49 nM). Inhibits Ras-induced malignant transformation and increases α-actin promoter-driven CAT activity in Ras-transformed cells. Has no effect on Ras-induced ERK and JNK activation. Inhibits Ras-induced membrane ruffling in REF-52 fibroblasts and blocks anchorage-independent growth of Ras-transformed tumor cell lines. Also induces DNA damage in SW480 colon cancer cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
Huber KV, Salah E, Radic B et al.
Nature -
SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway.
Walsh et al.
Oncogene, 1997;15:2553 -
SCH 51344, an inhibitor of RAS/RAC-mediated cell morphology pathway.
Kumar et al.
Ann.N.Y.Acad.Sci., 1999;886:122
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Citation for SCH 51344
The citations listed below are publications that use Tocris products. Selected citations for SCH 51344 include:
1 Citation: Showing 1 - 1
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1H-Pyrazolo[3,4-b]quinolines: Synthesis and Properties over 100 Years of Research.
Authors: Andrzej Et al.
Molecules 2022;27
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