SB 328437

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation.
   Abonyo BO, Alexander MS, Heiman AS.
   Am J Physiol Lung Cell Mol Physiol.
2. RANTES-mediated control of excitatory amino acid release in mouse spinal cord.
   Di Prisco S, Summa M, Chellakudam V, Rossi PI, Pittaluga A
   J. Neurochem., 2012;121(3):428-37.
3. Rapid transport of CCL11 across the blood-brain barrier: regional variation and importance of blood cells.
   Erickson, Michelle, Morofuji, Yoichi, Owen, Joshua B, Banks, William
   J Pharmacol Exp Ther, 2014;349(3):497-507.
4. Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.
   Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A
   Nat Commun, 2014;5(0):4715.
5. Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia
   JD Turner, N Pionnier, J Furlong-Si, H Sjoberg, S Cross, A Halliday, AF Guimaraes, DAN Cook, A Steven, N Van Rooije, JE Allen, SJ Jenkins, MJ Taylor
   PLoS Pathog., 2018;14(3):e1006949.
6. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration.
   White et al.
   J.Biol.Chem., 2000;275:36626
7. Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists.
   Mori et al.
   Int.Immunol., 2007;19:913

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