SB 297006

Catalog #: 4213 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
4213/10
4213/50

SB 297006 | CAS No. 58816-69-6 | Chemokine Receptor Antagonists

1 Image

Description: Potent and selective CCR3 antagonist

Chemical Name: N-Benzoyl-4-nitroaniline ethyl ester

Purity: ≥99%

View All Products for Chemokine Receptor Antagonists

Product Details

Supplemental Products

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SB 297006 is a potent and selective CCR3 antagonist (IC₅₀ = 39 nM). Displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 (IC₅₀ >27 μM). Inhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR3 (IC₅₀ values are 80, 90 and 210 nM respectively).

Technical Data

M.Wt:

342.35

Formula:

C₁₈H₁₈N₂O₅

Solubility:

Soluble to 100 mM in DMSO and to 20 mM in ethanol

Purity:

≥99%

Storage:

Store at RT

CAS No:

58816-69-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Quantitative structure-activity relationships of D- and L-N-actyl-alpha-aminoamide ligands binding to chymotrypsin. On the problem of combined treatment of stereoisomers.
Yoshimoto and Hansch
J.Org.Chem., 1976;41:2269
Identification of a potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration.
White et al.
J.Biol.Chem., 2000;275:36626

Product Datasheets

COA view current batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for SB 297006

There are currently no reviews for this product. Be the first to review SB 297006 and earn rewards!

Have you used SB 297006?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.