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(S)-(-)-Blebbistatin

Catalog #: 1852
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1852/1
(S)-(-)-Blebbistatin | CAS No. 856925-71-8 | Myosin Inhibitors
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Description: Selective inhibitor of myosin II ATPase activity. Active enantiomer of (±)-blebbistatin (Cat. No. 1760)

Chemical Name: (3aS)-(-)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(S)-(-)-Blebbistatin is a selective inhibitor of myosin II ATPase activity (IC50 ~0.5 - 5 μM); active enantiomer of (±)-blebbistatin. Inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. (S)-(-)-Blebbistatin rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.

Inactive Enantiomer and Racemate also available.

Technical Data

M.Wt:
292.34
Formula:
C18H16N2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
856925-71-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Specificity of blebbistatin, an inhibitor of myosin II.
    Limouze et al.
    J.Muscle Res.Cell Motil., 2004;25:337
  2. Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor.
    Straight et al.
    Science, 2003;299:1743
  3. Dissecting cytokinesis with small molecules.
    Straight et al.
    Amer.Soc.Cell Biol.Abstr., 2002;:2515

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Citations for (S)-(-)-Blebbistatin

The citations listed below are publications that use Tocris products. Selected citations for (S)-(-)-Blebbistatin include:

3 Citations: Showing 1 - 3

  1. P38 inhibition reverses TGFβ1 and TNFα-induced contraction in a model of proliferative vitreoretinopathy.
    Authors: Schiff Et al.
    Commun Biol  2019;2:162
  2. Real-time two- and three-dimensional imaging of monocyte motility and navigation on planar surfaces and in collagen matrices: roles of Rho.
    Authors: Bzymek Et al.
    Sci Rep  2016;6:25016
  3. Asymmetric division of contractile domains couples cell positioning and fate specification.
    Authors: Ma?tre Et al.
    Nature  2016;536:344

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