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RP 001 hydrochloride

Catalog #: 4289
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4289/10
4289/50
RP 001 hydrochloride | CAS No. 1781880-34-9 | Sphingosine-1-phosphate Receptor Agonists
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Description: Potent S1P1 agonist

Chemical Name: N-[4-[5-[3-Cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-β-alanine hydrochloride

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

RP 001 hydrochloride is a potent agonist of S1P1 receptors (EC50 = 9 pM). Induces internalization and polyubiquitination of S1P1 in vitro. Selective for S1P1 over S1P2 - S1P4.

Technical Data

M.Wt:
468.93
Formula:
C24H24N4O4.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1781880-34-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Actions of a picomolar short-acting S1P1 agonist in S1P1-eGFP knock-in mice.
    Cahalan et al.
    Nat.Chem.Biol., 2011;7:254

Product Datasheets

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Citations for RP 001 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for RP 001 hydrochloride include:

2 Citations: Showing 1 - 2

  1. RP001 hydrochloride improves neurological outcome after subarachnoid hemorrhage.
    Authors: Li Et al.
    J.Neurol.Sci.  2019;399:6
  2. Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.
    Authors: Masato Et al.
    Cell  2018;174:636-648.e18

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