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Rotigotine hydrochloride

Catalog #: 3896
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3896/10
3896/50
Rotigotine hydrochloride | CAS No. 125572-93-2 | Dopamine D2 Receptor Agonists
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Description: D2 and D3 agonist
Alternative Names: N 0923

Chemical Name: (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol hydrochloride

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Rotigotine hydrochloride is a dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Also has significant affinity for 5-HT1A and adrenergic α2B receptors. Exhibits antiparkinsonian acitivity.

Technical Data

M.Wt:
351.93
Formula:
C19H25NOS.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
125572-93-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease.
    Scheller et al.
    Naunyn.Schmiedebergs.Arch.Pharmacol., 2009;379:73

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Citation for Rotigotine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Rotigotine hydrochloride include:

1 Citation: Showing 1 - 1

  1. DA D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework.
    Authors: Fernández-Dueñas Et al.
    J Exp Clin Cancer Res  2013;63:42

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