Rhosin hydrochloride
Chemical Name: D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
Purity: ≥98%
Biological Activity
Rhosin hydrochloride is a Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors.
Shang et al.
Proc.Natl.Acad.Sci.U.S.A., 2013;110:3155 -
Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases.
Shang et al.
Chem.Biol., 2012;19:699 -
Sphingosine 1-phosphate receptor type 2 positively regulates interleukin (IL)-4/IL-13-induced STAT6 phosphorylation
Y Okamoto, K Kitakaze, Y Takenouchi, S Yamamoto, H Ishimaru, K Tsuboi
Cellular Signalling, 2021;88(0):110156.
Product Datasheets
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Citations for Rhosin hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Rhosin hydrochloride include:
7 Citations: Showing 1 - 7
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Unique osteogenic profile of bone marrow stem cells stimulated in perfusion bioreactor is Rho-ROCK-mediated contractility dependent.
Authors: Thomas Et al.
Bioeng Transl Med 2023;8:e10509
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Gadolinium-based contrast agent accelerates the migration of astrocyte via integrin αvβ3 signaling pathway
Authors: Ariyani Et al.
Sci.Rep 2022;12:5850
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Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection.
Authors: Wenming Et al.
Commun Biol 2021;4:1239
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β2-adrenergic receptor regulates ER-mitochondria contacts.
Authors: Ginam Et al.
Sci Rep 2021;11:21477
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Nonionotropic Action of Endothelial NMDA Receptors on Blood-Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin.
Authors: Richard Et al.
J Neurosci 2020;40:1778-1787
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Protein Arginine Methyltransferase 1 (PRMT1) Selective Inhibitor, TC-E 5003, Has Anti-Inflammatory Properties in TLR4 Signaling.
Authors: Keejung Et al.
Int J Mol Sci 2020;21
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The p75NTR Influences Cerebellar Circuit Development and Adult Behavior via Regulation of Cell Cycle Duration of Granule Cell Progenitors.
Authors: Ying Et al.
J Neurosci 2019;39:9119-9129
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