Recombinant Rhesus Macaque/Cynomolgus IFN-alpha Protein Summary
Product Specifications
Interferon was titrated with the use of the cytopathic effect inhibition assay as listed. The protein has similar activity to Human IFN Alpha 2 on human, rhesus and bovine cells.
Bovine (MDBK/VSV) – performed as described [Rubinstein et al. (1981) J. Virol. 37(2):755] The EC50 for interferon in this assay is ~5 U/ml.
Human (A549/EMCV) – performed as described [Budd et al. (1985) Canc. Chem. Pharm. 12:39]. The EC50 for interferon in this assay is ~1 U/ml.
Product Datasheets
14110-1
| Formulation | Phosphate buffered saline (PBS) containing 0.1% bovine serum albumin (BSA) |
| Shipping | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date. |
Reconstitution Calculator
Background: IFN-alpha
Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.
Citation for Recombinant Rhesus Macaque/Cynomolgus IFN-alpha Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer.
Authors: Dudek AZ, Yunis C, Harrison LI, Kumar S, Hawkinson R, Cooley S, Vasilakos JP, Gorski KS, Miller JS
Clin. Cancer Res., 2007-12-01;13(23):7119-25.
Species: Human
Sample Types: Serum
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