Recombinant Human Ubiquitin Protein, CF

Redirecting the specificity of tripartite motif containing-21 scaffolds using a novel discovery and design approach
Authors: VanDyke, D;Xu, L;Sargunas, PR;Gilbreth, RN;Baca, M;Gao, C;Hunt, J;Spangler, JB;
The Journal of biological chemistry
Species: N/A
Sample Types: Recombinant Protein
Applications: Bioassay

UV-B irradiation-activated E3 ligase GmILPA1 modulates gibberellin catabolism to increase plant height in soybean
Authors: Sun, J;Huang, S;Lu, Q;Li, S;Zhao, S;Zheng, X;Zhou, Q;Zhang, W;Li, J;Wang, L;Zhang, K;Zheng, W;Feng, X;Liu, B;Kong, F;Xiang, F;
Nature communications
Species: N/A
Sample Types: Recombinant Protein
Applications: Bioassay

Ubiquitin-driven protein condensation promotes clathrin-mediated endocytosis
Authors: Yuan, F;Gollapudi, S;Day, KJ;Ashby, G;Sangani, A;Malady, BT;Wang, L;Lafer, EM;Huibregtse, JM;Stachowiak, JC;
bioRxiv : the preprint server for biology
Species: N/A
Sample Types: Recombinant Protein
Applications: Bioassay

The ubiquitin-like modifier FAT10 covalently modifies HUWE1 and strengthens the interaction of AMBRA1 and HUWE1
Authors: Mueller, S;Bialas, J;Ryu, S;Catone, N;Aichem, A;
PloS one
Species: N/A
Sample Types: Recombinant Protein
Applications: Bioassay

Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma
Authors: Li, Y;Wang, H;Sun, B;Su, G;Cang, Y;Zhao, L;Zhao, S;Li, Y;Mao, B;Ma, P;
Cell death & disease
Species: N/A
Sample Types: Protein
Applications: Bioassay

Identification of XAF1 as an endogenous AKT inhibitor
Authors: Chen, M;Wang, K;Han, Y;Yan, S;Yuan, H;Liu, Q;Li, L;Li, N;Zhu, H;Lu, D;Wang, K;Liu, F;Luo, D;Zhang, Y;Jiang, J;Li, D;Zhang, L;Ji, H;Zhou, H;Chen, Y;Qin, J;Gao, D;
Cell reports
Species: N/A
Sample Types: Recombinant Protein
Applications: Bioassay

Parkin Precipitates on Mitochondria via Aggregation and Autoubiquitination
Authors: Ardah, MT;Radwan, N;Khan, E;Kitada, T;Haque, ME;
International journal of molecular sciences
Species: N/A
Sample Types: Recombinant Protein
Applications: Bioassay

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
Authors: Monda, JK;Ge, X;Hunkeler, M;Donovan, KA;Ma, MW;Jin, CY;Leonard, M;Fischer, ES;Bennett, EJ;
Cell reports
Species: N/A
Sample Types: Recombinant Protein
Applications: Bioassay

The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus
Authors: L Kong, C Sui, T Chen, L Zhang, W Zhao, Y Zheng, B Liu, X Cheng, C Gao
Cell Reports, 2023-03-26;42(4):112306.
Species: Human
Sample Types: Whole Cells
Applications: Ubiquitination

Calpain activity is negatively regulated by a KCTD7-Cullin-3 complex via non-degradative ubiquitination
Authors: J Sharma, S Mulherkar, UI Chen, Y Xiong, L Bajaj, BK Cho, YA Goo, HE Leung, KF Tolias, M Sardiello
Cell Discovery, 2023-03-24;9(1):32.
Species: Human
Sample Types: Whole Cells
Applications: Ubiquitination

Structure and functional determinants of Rad6-Bre1 subunits in the histone H2B ubiquitin-conjugating complex
Authors: PK Shukla, JE Bissell, S Kumar, S Pokhrel, S Palani, KS Radmall, O Obidi, TJ Parnell, J Brasch, DC Shrieve, MB Chandrasek
Nucleic Acids Research, 2023-03-21;0(0):.
Species: N/A
Sample Types: Recombinant Protein
Applications: Bioassay

A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma
Authors: X Du, J Pang, B Gu, T Si, Y Chang, T Li, M Wu, Z Wang, Y Wang, J Feng, N Wu, J Man, H Li, A Li, T Zhang, B Wang, X Duan
Nucleic Acids Research, 2023-02-22;0(0):.
Species: N/A
Sample Types: Recombinant Protein
Applications: Bioassay

TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away
Authors: TET Mevissen, AV Prasad, JC Walter
Cell Reports, 2023-02-18;42(2):112125.
Species: N/A
Sample Types: Recombinant Protein
Applications: Bioassay

Lysine 222 in PPAR gamma1 functions as the key site of MuRF2-mediated ubiquitination modification
Authors: Y Fan, F Xu, R Wang, J He
Scientific Reports, 2023-02-03;13(1):1999.
Species: Human
Sample Types: Whole Cells
Applications: Ubiquitination

Calpain activity is negatively regulated by a KCTD7-Cullin-3 complex via non-degradative ubiquitination
Authors: J Sharma, S Mulherkar, UI Chen, Y Xiong, L Bajaj, BK Cho, YA Goo, HE Leung, KF Tolias, M Sardiello
Cell Discovery, 2023;9(1):32.
Species: Human
Sample Types: Whole Cells
Applications: Ubiquitination

MaNAC029 modulates ethylene biosynthesis and fruit quality and undergoes MaXB3-mediated proteasomal degradation during banana ripening
Authors: W Wei, YY Yang, JY Chen, P Lakshmanan, JF Kuang, WJ Lu, W Shan
Journal of advanced research, 2022-12-15;0(0):.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

The cysteine residue in beta-lactoglobulin reacts with oxidized tyrosine residues in beta-casein to give casein-lactoglobulin dimers
Authors: L Doblas, PM Hägglund, E Fuentes-Le, MJ Davies
Archives of biochemistry and biophysics, 2022-11-28;733(0):109482.
Species: Human
Sample Types: Protein
Applications: Bioassay

VpdC is a ubiquitin-activated phospholipase effector that regulates Legionella vacuole expansion during infection
Authors: X Li, DE Anderson, YY Chang, M Jarnik, MP Machner
Proceedings of the National Academy of Sciences of the United States of America, 2022-11-21;119(48):e2209149119.
Species: N/A
Sample Types: Cell Lysates
Applications: Bioassay

Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy
Authors: TT Liu, H Yang, FF Zhuo, Z Yang, MM Zhao, Q Guo, Y Liu, D Liu, KW Zeng, PF Tu
EBioMedicine, 2022-11-11;86(0):104353.
Species: Human
Sample Types: Cell Lysates
Applications: Bioassay

Cooperative assembly of p97 complexes involved in replication termination
Authors: OV Kochenova, S Mukkavalli, M Raman, JC Walter
Nature Communications, 2022-11-03;13(1):6591.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

An alpha/beta hydrolase family member negatively regulates salt tolerance but promotes flowering through three distinct functions in rice
Authors: YH Xiang, JJ Yu, B Liao, JX Shan, WW Ye, NQ Dong, T Guo, Y Kan, H Zhang, YB Yang, YC Li, HY Zhao, HX Yu, ZQ Lu, HX Lin
Molecular plant, 2022-10-27;0(0):.
Species: Plant - Oryza sativa (Rice)
Sample Types: Recombinant Protein
Applications: Bioassay

DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates
Authors: K Zhu, MJ Suskiewicz, A Hloušek-Ka, H Meudal, A Miko?, V Aucagne, D Ahel, I Ahel
Science Advances, 2022-10-05;8(40):eadd4253.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

Inhibition of UBA6 by inosine augments tumour immunogenicity and responses
Authors: L Zhang, L Jiang, L Yu, Q Li, X Tian, J He, L Zeng, Y Yang, C Wang, Y Wei, X Jiang, J Li, X Ge, Q Gu, J Li, D Wu, AJ Sadler, D Yu, D Xu, Y Gao, X Yuan, B He
Nature Communications, 2022-09-15;13(1):5413.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling
Authors: X Ma, X Ma, L Zhu, Y Zhao, M Chen, T Li, Y Lin, D Ma, C Sun, L Han
Oncogenesis, 2022-07-20;11(1):40.
Species: Human
Sample Types: Recombinant Proteins
Applications: Bioassay

USP14-regulated allostery of the human proteasome by time-resolved cryo-EM
Authors: S Zhang, S Zou, D Yin, L Zhao, D Finley, Z Wu, Y Mao
Nature, 2022-04-27;605(7910):567-574.
Species: Human
Sample Types: Recombinant Proteins
Applications: Bioassay

Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription
Authors: SB Lee, L Garofano, A Ko, F D'Angelo, B Frangaj, D Sommer, Q Gan, K Kim, T Cardozo, A Iavarone, A Lasorella
Nature Communications, 2022-04-19;13(1):2089.
Species: Human
Sample Types: Cell Lysates
Applications: Bioassay

Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6
Authors: D Deshmukh, J Xu, X Yang, H Shimelis, S Fang, Y Qiu
Pharmaceutics, 2022-04-06;14(4):.
Species: N/A
Sample Types: Recombinant Protein
Applications: Bioassay

Two distinct classes of co-chaperones compete for the EEVD motif in heat shock protein 70 (Hsp70) to tune its chaperone activities
Authors: OT Johnson, CM Nadel, EC Carroll, T Arhar, JE Gestwicki
The Journal of Biological Chemistry, 2022-02-09;0(0):101697.
Species: Human
Sample Types: Recombinant Proteins
Applications: Bioassay

Host E3 ligase HUWE1 attenuates the pro-apoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation
Authors: Y Zhou, R Zheng, S Liu, C Disoma, A Du, S Li, Z Chen, Z Dong, Y Zhang, S Li, P Liu, A Razzaq, X Chen, Y Liao, S Tao, Y Liu, L Xu, Q Zhang, J Peng, X Deng, S Li, T Jiang, Z Xia
The Journal of Biological Chemistry, 2022-01-13;0(0):101584.
Species: Human
Sample Types: Recombinant Proteins
Applications: Bioassay

Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes
Authors: S Yoon, K Bogdanov, D Wallach
Cell Death and Differentiation, 2022-01-09;0(0):.
Species: Human
Sample Types: Protein
Applications: Bioassay

MaNAC029 modulates ethylene biosynthesis and fruit quality and undergoes MaXB3-mediated proteasomal degradation during banana ripening
Authors: W Wei, YY Yang, JY Chen, P Lakshmanan, JF Kuang, WJ Lu, W Shan
Journal of advanced research, 2022;0(0):.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates
Authors: H Zhou, MS Zaher, JC Walter, A Brown
Nucleic Acids Research, 2021-12-16;49(22):13194-13206.
Species: N/A
Sample Types: Recombinant Protein
Applications: Bioassay

Effect of macromolecular crowding on protein oxidation: Consequences on the rate, extent and oxidation pathways
Authors: E Fuentes-Le, JS Reyes, LF Gamon, C López-Alar, MJ Davies
Redox Biology, 2021-11-27;48(0):102202.
Species: Human
Sample Types: Peptide
Applications: Bioassay

ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-kappaB
Authors: M Won, KA Park, S Kim, E Ju, Y Ko, H Yoo, H Ro, J Lee, J Oh, EG Lee, SY Kim, SW Nam, HM Shen, MK Yeo, JM Kim, GM Hur
Cell Death and Differentiation, 2021-11-27;0(0):.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer
Authors: C Mukhopadhy, C Yang, L Xu, D Liu, Y Wang, D Huang, LD Deonarine, J Cyrta, E Davicioni, A Sboner, BD Robinson, AM Chinnaiyan, MA Rubin, CE Barbieri, P Zhou
Nature Communications, 2021-11-18;12(1):6662.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination
Authors: Q Zhu, J Huang, H Huang, H Li, P Yi, JA Kloeber, J Yuan, Y Chen, M Deng, K Luo, M Gao, G Guo, X Tu, P Yin, Y Zhang, J Su, J Chen, Z Lou
Nature Communications, 2021-11-17;12(1):6653.
Species: Human
Sample Types: Recombinant Proteins
Applications: Bioassay

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
Authors: T Mahlokozer, B Patel, H Chen, P Desouza, X Qu, DD Mao, D Hafez, W Yang, R Taiwo, M Paturu, A Salehi, AD Gujar, GP Dunn, N Mosammapar, AA Petti, H Yano, AH Kim
Nature Communications, 2021-11-03;12(1):6321.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

The San1 Ubiquitin Ligase Avidly Recognizes Misfolded Proteins through Multiple Substrate Binding Sites
Authors: R Ibarra, HR Borror, B Hart, RG Gardner, G Kleiger
Biomolecules, 2021-11-02;11(11):.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

BRCA1-BARD1 regulates transcription through modulating topoisomerase IIbeta
Authors: H Bunch, J Jeong, K Kang, DS Jo, ATQ Cong, D Kim, D Kim, DH Cho, YM Lee, BPC Chen, MJ Schellenbe, SK Calderwood
Open Biology, 2021-10-06;11(10):210221.
Species: Human
Sample Types: Recombinant Protein
Applications: Enzyme Assay

FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX
Authors: RK Manne, Y Agrawal, SK Malonia, S Banday, S Edachery, A Patel, A Kumar, P Shetty, MK Santra
The Journal of Biological Chemistry, 2021-09-26;0(0):101253.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response
Authors: Y Liu, C Qin, Y Rao, C Ngo, JJ Feng, J Zhao, S Zhang, TY Wang, J Carriere, AC Savas, M Zarinfar, S Rice, H Yang, W Yuan, JA Camarero, J Yu, XS Chen, C Zhang, P Feng
MBio, 2021-09-21;0(0):e0233521.
Species: E. coli, Human
Sample Types: Recombinant Protein
Applications: Bioassay

Structural basis of human transcription-DNA repair coupling
Authors: G Kokic, FR Wagner, A Chernev, H Urlaub, P Cramer
Nature, 2021-09-15;0(0):.
Species: Human
Sample Types: Recombinant Proteins
Applications: Bioassay

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
Authors: Y Sun, J Chen, SN Huang, YP Su, W Wang, K Agama, S Saha, LM Jenkins, JM Pascal, Y Pommier
Nature Communications, 2021-08-18;12(1):5010.
Species: Human
Sample Types:
Applications: Bioassay

Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W
Authors: CW Davies, SE Vidal, L Phu, J Sudhamsu, TB Hinkle, S Chan Rosen, FR Schumacher, YJ Zeng, C Schwerdtfe, AS Peterson, JR Lill, CM Rose, AS Shaw, IE Wertz, DS Kirkpatric, JT Koerber
Nature Communications, 2021-07-29;12(1):4608.
Species: Human
Sample Types: Recombinant Proteins
Applications: Bioassay

The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization
Authors: W Li, Y Wang, L Zhu, S Du, J Mao, Y Wang, S Wang, Q Bo, Y Tu, Q Yi
Journal of Cellular and Molecular Medicine, 2021-05-31;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology
Authors: W El Manaa, E Duplan, T Goiran, I Lauritzen, L Vaillant B, S Lacas-Gerv, VA Morais, H You, L Qi, M Salazar, U Ozcan, M Chami, F Checler, C Alves da C
Autophagy, 2021-05-24;0(0):1-23.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3
Authors: P Gao, X Ma, M Yuan, Y Yi, G Liu, M Wen, W Jiang, R Ji, L Zhu, Z Tang, Q Yu, J Xu, R Yang, S Xia, M Yang, J Pan, H Yuan, H An
Nature Communications, 2021-02-19;12(1):1194.
Species: Human
Sample Types: Cell Lysates
Applications: Ubiquitination

A ubiquitin switch controls autocatalytic inactivation of the DNA-protein crosslink repair protease SPRTN
Authors: S Zhao, A Kieser, HY Li, HK Reinking, P Weickert, S Euteneuer, D Yaneva, AC Acampora, MJ Götz, R Feederle, J Stingele
Nucleic Acids Research, 2021-01-25;0(0):.
Species: Human
Sample Types: Protein
Applications: Bioassay

Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples
Authors: JO Watzlawik, X Hou, D Fricova, C Ramnarine, SK Barodia, TF Gendron, MG Heckman, M DeTure, J Siuda, ZK Wszolek, CR Scherzer, OA Ross, G Bu, DW Dickson, MS Goldberg, FC Fiesel, W Springer
Autophagy, 2020-10-28;0(0):1-16.
Species: Human
Sample Types: N/A
Applications: Western Blot

Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents
Authors: M Deng, J Lin, S Nowsheen, T Liu, Y Zhao, PW Villalta, D Sicard, DJ Tschumperl, S Lee, J Kim, Z Lou
Science Advances, 2020-09-11;6(37):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage
Authors: MC Albert, K Brinkmann, W Pokrzywa, SD Günther, M Krönke, T Hoppe, H Kashkar
Cell Death & Disease, 2020-09-10;11(9):740.
Species: Human
Sample Types: Whole Cells
Applications: Ubiquitylation

Crystal structure of GCN5 PCAF�N-terminal domain reveals atypical ubiquitin ligase structure
Authors: ST Fukai, R Hibi, T Naganuma, M Sakai, S Saijo, N Shimizu, M Matsumoto, T Shimizu
J. Biol. Chem., 2020-08-19;0(0):.
Species: Human, Mouse
Sample Types: Protein, Whole Cells
Applications: Bioassay, Ubiquitination

Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer
Authors: AM Cathcart, GH Bird, TE Wales, HD Herce, EP Harvey, ZJ Hauseman, CE Newman, U Adhikary, MS Prew, T Oo, S Lee, JR Engen, LD Walensky
Nat. Chem. Biol., 2020-08-17;0(0):.
Species: E. coli, Human, N/A
Sample Types: Cell Lysates, Peptide, Protein
Applications: Bioassay

The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency
Authors: M Gatti, R Imhof, Q Huang, M Baudis, M Altmeyer
Cell Rep, 2020-08-04;32(5):107985.
Species: Human
Sample Types: Protein
Applications: Bioassay

PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis
Authors: CR Kim, T Noda, H Kim, G Kim, S Park, Y Na, S Oura, K Shimada, I Bang, JY Ahn, YR Kim, SK Oh, HJ Choi, JS Kim, I Jung, H Lee, Y Okada, M Ikawa, SH Baek
Cell Rep, 2020-07-28;32(4):107950.
Species: Mouse
Sample Types: Protein
Applications: Bioassay

Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex
Authors: ME Matyskiela, T Clayton, X Zheng, C Mayne, E Tran, A Carpenter, B Pagarigan, J McDonald, M Rolfe, LG Hamann, G Lu, PP Chamberlai
Nat. Struct. Mol. Biol., 2020-04-06;27(4):319-322.
Species: Spodoptera frugiperda
Sample Types: Whole Cells
Applications: Ubiquitination

piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis
Authors: F Li, P Yuan, M Rao, CH Jin, W Tang, YF Rong, YP Hu, F Zhang, T Wei, Q Yin, T Liang, L Wu, J Li, D Li, Y Liu, W Lou, S Zhao, MF Liu
Nat. Cell Biol., 2020-03-16;0(0):.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

Mitochondria ubiquitin ligase, MARCH5 resolves hepatitis B virus X protein aggregates in the liver pathogenesis
Authors: YS Yoo, YJ Park, HS Lee, NTK Oanh, MY Cho, J Heo, ES Lee, H Cho, YY Park, H Cho
Cell Death Dis, 2019-12-09;10(12):938.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

Competitive ubiquitination activates the tumor suppressor p53
Authors: X Li, M Guo, L Cai, T Du, Y Liu, HF Ding, H Wang, J Zhang, X Chen, C Yan
Cell Death Differ., 2019-12-02;0(0):.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15
Authors: TC Ting, M Goralski, K Klein, B Wang, J Kim, Y Xie, D Nijhawan
Cell Rep, 2019-11-05;29(6):1499-1510.e6.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response
Authors: J Sitz, SA Blanchet, SF Gameiro, E Biquand, TM Morgan, M Galloy, J Dessapt, EG Lavoie, A Blondeau, BC Smith, JS Mymryk, CA Moody, A Fradet-Tur
Proc. Natl. Acad. Sci. U.S.A., 2019-09-09;116(39):19552-19562.
Species: Virus - HPV
Sample Types: Recombinant Protein
Applications: Bioassay

Uncoupling of p97 ATPase activity has a dominant negative effect on protein extraction
Authors: HB Rycenga, KB Wolfe, ES Yeh, DT Long
Sci Rep, 2019-07-17;9(1):10329.
Species: Xenopus
Sample Types: Egg Extract
Applications: Bioassay

Cbl interacts with multiple E2s in vitro and in cells
Authors: MS Liyasova, K Ma, D Voeller, PE Ryan, J Chen, RE Klevit, S Lipkowitz
PLoS ONE, 2019-05-23;14(5):e0216967.
Species: Human
Sample Types: Recombinant Protein
Applications: Ubiquitination

K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling
Authors: Q Yin, T Han, B Fang, G Zhang, C Zhang, ER Roberts, V Izumi, M Zheng, S Jiang, X Yin, M Kim, J Cai, EB Haura, JM Koomen, KSM Smalley, L Wan
Nat Commun, 2019-04-23;10(1):1870.
Species: Human
Sample Types: Recombinant Protein
Applications: Ubiquitination

DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination
Authors: OE Akande, PK Damle, M Pop, NE Sherman, BB Szomju, LV Litovchick, SR Grossman
Cell Rep, 2019-03-19;26(12):3323-3335.e4.
Applications: Bioassay

The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways
Authors: CM Xie, M Tan, XT Lin, D Wu, Y Jiang, Y Tan, H Li, Y Ma, X Xiong, Y Sun
Cell Rep, 2019-03-12;26(11):3037-3050.e4.
Applications: Bioassay

MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner
Authors: B Liu, J Yi, X Yang, L Liu, X Lou, Z Zhang, H Qi, Z Wang, J Zou, WG Zhu, W Gu, J Luo
Oncogene, 2018-12-07;0(0):.
Species: Human
Sample Types: Protein
Applications: Bioassay

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
Authors: Y Dong, S Zhang, Z Wu, X Li, WL Wang, Y Zhu, S Stoilova-M, Y Lu, D Finley, Y Mao
Nature, 2018-11-12;0(0):.
Species: Human
Sample Types: Protein
Applications: Bioassay

XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation
Authors: X Huang, XN Wang, XD Yuan, WY Wu, PE Lobie, Z Wu
Oncogene, 2018-10-01;0(0):.
Species: Human
Sample Types: Protein
Applications: Bioassay

SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate
Authors: ME Matyskiela, S Couto, X Zheng, G Lu, J Hui, K Stamp, C Drew, Y Ren, M Wang, A Carpenter, CW Lee, T Clayton, W Fang, CC Lu, M Riley, P Abdubek, K Blease, J Hartke, G Kumar, R Vessey, M Rolfe, LG Hamann, PP Chamberlai
Nat. Chem. Biol., 2018-09-06;0(0):.
Species: Human
Sample Types: Recombinant Protein
Applications: Ubiquitination

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome
Authors: KA Donovan, J An, RP Nowak, JC Yuan, EC Fink, BC Berry, BL Ebert, ES Fischer
Elife, 2018-08-01;7(0):.
Species: Human
Sample Types: Protein
Applications: Ubiquitination

Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease
Authors: X Hou, FC Fiesel, D Truban, M Castanedes, WL Lin, AI Soto, P Tacik, LG Rousseau, NN Diehl, MG Heckman, O Lorenzo-Be, I Ferrer, JM Arbelo, JC Steele, MJ Farrer, M Cornejo-Ol, L Torres, IF Mata, NR Graff-Radf, ZK Wszolek, OA Ross, ME Murray, DW Dickson, W Springer
Autophagy, 2018-07-28;14(8):1404-1418.
Applications: Bioassay

Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila
Authors: D Valleau, AT Quaile, H Cui, X Xu, E Evdokimova, C Chang, ME Cuff, ML Urbanus, S Houliston, CH Arrowsmith, AW Ensminger, A Savchenko
Cell Rep, 2018-04-10;23(2):568-583.
Applications: Bioassay

CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells
Authors: S Ito, A Ueno, T Ueda, H Nakagawa, H Taniguchi, N Kayukawa, A Fujihara-I, F Hongo, K Okihara, O Ukimura
Oncotarget, 2018-04-03;9(25):17645-17655.
Applications: Bioassay

Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors
Authors: TR de Moura, S Mozaffari-, CZK Szabó, J Schmitzová, O Dybkov, C Cretu, M Kachala, D Svergun, H Urlaub, R Lührmann, V Pena
Mol. Cell, 2018-03-15;69(6):979-992.e6.
Species: Bacteria
Sample Types: Cell Lysates
Applications: Bioassay

The E3 ubiquitin ligase Siah-1 suppresses avian reovirus infection by targeting p10 for degradation
Authors: X Chen, Z He, M Fu, Y Wang, H Wu, X Li, H Cao, SJ Zheng
J. Virol., 2018-02-26;0(0):.
Applications: Bioassay

HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer
Authors: SY Kim, HJ Kim, HJ Kim, DH Kim, CH Kim, JH Han, HK Byeon, K Lee
Autophagy, 2018-02-21;0(0):1-89.
Species: Human
Sample Types: Cell Lysates
Applications: Bioassay

Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7
Authors: M Higa, K Tanaka, M Saijo
FEBS J., 2018-01-25;0(0):.
Applications: Bioassay

Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle
Authors: LJ Albee, HM LaPorte, X Gao, JM Eby, YH Cheng, AM Nevins, BF Volkman, V Gaponenko, M Majetschak
Open Biol, 2018-01-01;8(1):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A20 regulates the DNA damage response and mediates tumor cell resistance to DNA damaging therapy
Authors: C Yang, W Zang, Z Tang, Y Ji, R Xu, Y Yang, A Luo, B Hu, Z Zhang, Z Liu, X Zheng
Cancer Res., 2017-12-12;0(0):.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

Distinct kinetics of serine and threonine dephosphorylation are essential for mitosis
Authors: JB Hein, EPT Hertz, DH Garvanska, T Kruse, J Nilsson
Nat. Cell Biol., 2017-10-30;19(12):1433-1440.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons
Authors: M Boselli, BH Lee, J Robert, MA Prado, SW Min, C Cheng, MC Silva, C Seong, S Elsasser, KM Hatle, TC Gahman, SP Gygi, SJ Haggarty, L Gan, RW King, D Finley
J. Biol. Chem., 2017-09-26;0(0):.
Species: Human
Sample Types: Protein
Applications: Enzyme Assay

Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114
Authors: B Lin, Q Ke, H Li, NS Pheifer, DC Velliquett, DW Leaman
Cytokine, 2017-07-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing
Authors: BA Osuna, CJ Howard, S Kc, A Frost, DE Weinberg
Elife, 2017-07-18;6(0):.
Species: Yeast - Saccharomyces cerevisiae
Sample Types: RNA
Applications: Bioassay

Plk1 phosphorylation of CAP-H2 triggers chromosome condensation by condensin II at the early phase of mitosis
Authors: Y Kagami, M Ono, K Yoshida
Sci Rep, 2017-07-17;7(1):5583.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation
Authors: A Bononi, C Giorgi, S Patergnani, D Larson, K Verbruggen, M Tanji, L Pellegrini, V Signorato, F Olivetto, S Pastorino, M Nasu, A Napolitano, G Gaudino, P Morris, G Sakamoto, LK Ferris, A Danese, A Raimondi, C Tacchetti, S Kuchay, HI Pass, EB Affar, H Yang, P Pinton, M Carbone
Nature, 2017-06-14;546(7659):549-553.
Applications: Bioassay

The Banana Fruit SINA Ubiquitin Ligase MaSINA1 Regulates the Stability of MaICE1 to be Negatively Involved in Cold Stress Response
Authors: ZQ Fan, JY Chen, JF Kuang, WJ Lu, W Shan
Front Plant Sci, 2017-06-12;8(0):995.
Applications: Bioassay

RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination
Authors: S Inano, K Sato, Y Katsuki, W Kobayashi, H Tanaka, K Nakajima, S Nakada, H Miyoshi, K Knies, A Takaori-Ko, D Schindler, M Ishiai, H Kurumizaka, M Takata
Mol. Cell, 2017-06-01;66(5):622-634.e8.
Species: Human
Sample Types: Protein
Applications: Enzyme Assay

DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues
Authors: V Glorian, J Allègre, J Berthelet, B Dumetier, PM Boutanquoi, N Droin, C Kayaci, J Cartier, S Gemble, G Marcion, D Gonzalez, R Boidot, C Garrido, O Michaud, E Solary, L Dubrez
Cell Death Dis, 2017-05-25;8(5):e2816.
Species: Bacteria - E. Coli, Human
Sample Types: Protein, Recombinant Protein
Applications: Bioassay

pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4(CRBN) ubiquitin ligase
Authors: J An, CM Ponthier, R Sack, J Seebacher, MB Stadler, KA Donovan, ES Fischer
Nat Commun, 2017-05-22;8(0):15398.
Applications: Bioassay

RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage
Authors: A Paul, B Wang
Mol. Cell, 2017-05-18;66(4):458-472.e5.
Applications: Bioassay

Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex
Authors: NO Bodnar, TA Rapoport
Cell, 2017-05-04;169(4):722-735.e9.
Applications: Bioassay

In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins
Authors: Y Pakdaman, M Sanchez-Gu, R Kleppe, S Erdal, HJ Bustad, L Bjørkhaug, K Haugarvoll, C Tzoulis, K Heimdal, PM Knappskog, S Johansson, I Aukrust
Biosci. Rep., 2017-04-28;37(2):.
Species: Human
Sample Types: Protein
Applications: Bioassay

Prefoldins Negatively Regulate Cold Acclimation in Arabidopsis Thaliana By Promoting Nuclear Proteasome-Mediated HY5 Degradation
Authors: C Perea-Resa, MA Rodríguez-, E Iniesto, V Rubio, J Salinas
Mol Plant, 2017-04-12;0(0):.
Applications: Bioassay

Development of ?-Hairpin Peptides for the Measurement of SCF-Family E3 Ligase Activity in Vitro via Ornithine Ubiquitination
Authors: KM Houston, AT Melvin, GS Woss, EL Fayer, ML Waters, NL Allbritton
ACS Omega, 2017-03-29;2(3):1198-1206.
Species: Human
Sample Types: Protein
Applications: Bioassay

H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis
Authors: X Zhang, B Li, AH Rezaeian, X Xu, PC Chou, G Jin, F Han, BS Pan, CY Wang, J Long, A Zhang, CY Huang, FJ Tsai, CH Tsai, C Logothetis, HK Lin
Nat Commun, 2017-03-16;8(0):14799.
Applications: Bioassay

RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor ? signaling
Authors: RJ Malonis, W Fu, MJ Jelcic, M Thompson, BS Canter, M Tsikitis, FJ Esteva, I Sánchez
J. Biol. Chem., 2017-03-14;292(18):7435-7451.
Applications: Bioassay

The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response
Authors: Q Wang, L Huang, Z Hong, Z Lv, Z Mao, Y Tang, X Kong, S Li, Y Cui, H Liu, L Zhang, X Zhang, L Jiang, C Wang, Q Zhou
PLoS Pathog, 2017-03-08;13(3):e1006264.
Applications: Bioassay

The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function
Authors: S He, Y Cao, P Xie, G Dong, L Zhang
Sci Rep, 2017-02-07;7(0):41364.
Species: Human
Sample Types: Cell Lysates
Applications: Bioassay

Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL
Authors: E Hasanov, G Chen, P Chowdhury, J Weldon, Z Ding, E Jonasch, S Sen, CL Walker, R Dere
Oncogene, 2017-01-23;0(0):.
Applications: Ubiquitination

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity
Authors: Xueting Lang
J. Exp. Med, 2016-12-28;0(0):.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

Monoubiquitination Inhibits the Actin Bundling Activity of Fascin
Authors: Shengyu Yang
J. Biol. Chem., 2016-11-22;0(0):.
Applications: Bioassay

Regulation of the MDM2-p53 pathway by the nucleolar protein CSIG in response to nucleolar stress
Sci Rep, 2016-11-04;6(0):36171.
Species: Human
Sample Types: Protein
Applications: Bioassay

Structural insights into Parkin substrate lysine targeting from minimal Miro substrates
Sci Rep, 2016-09-08;6(0):33019.
Species: Human
Sample Types: Protein
Applications: Bioassay

Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage
Clin Cancer Res, 2016-09-02;0(0):.
Species: Human
Sample Types: Protein
Applications: Ubiquitination

Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal
Nat Commun, 2016-07-28;7(0):12326.
Applications: Bioassay

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase
Authors: Mary E Matyskiela
Nature, 2016-06-22;0(0):.
Applications: Bioassay

Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles
EMBO J, 2016-05-23;0(0):.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4
Authors: Q Zhang, D Karnak, M Tan, TS Lawrence, MA Morgan, Y Sun
Mol. Cell, 2016-01-07;61(3):419-33.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

An anti-ubiquitin antibody response in transitional cell carcinoma of the urinary bladder.
Authors: Ardelt P, Ebbing J, Adams F, Reiss C, Arap W, Pasqualini R, Bachmann A, Wetterauer U, Riedmiller H, Kneitz B
PLoS ONE, 2015-03-05;10(3):e0118646.
Species: Human
Sample Types: Serum
Applications: ELISA

Stochastic gate dynamics regulate the catalytic activity of ubiquitination enzymes.
Authors: Rout, Manoj K, Hodge, Curtis D, Markin, Craig J, Xu, Xin, Glover, J N Mark, Xiao, Wei, Spyracopoulos, Leo
J Am Chem Soc, 2014-12-05;136(50):17446-58.
Applications: Bioassay

Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations.
Authors: Sandoval D, Hill S, Ziemba A, Lewis S, Kuhlman B, Kleiger G
J Biol Chem, 2014-11-25;290(2):1106-18.
Species: Bacteria - E. Coli
Sample Types: Whole Cells

A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum.
Authors: Sanchez C, Liu C, Mayer S, Nurhasanah A, Cyrklaff M, Mu J, Ferdig M, Stein W, Lanzer M
PLoS Genet, 2014-05-15;10(5):e1004382.
Species: Parasite - Plasmodium falciparum
Sample Types: Protein
Applications: Ubiquitination

Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity.
Authors: Guicciardi, Maria Eu, Werneburg, Nathan W, Bronk, Steven F, Franke, Adrian, Yagita, Hideo, Thomas, Gary, Gores, Gregory
PLoS ONE, 2014-03-14;9(3):e92124.
Applications: Bioassay

The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2.
Authors: Townley-Tilson, W H Davi, Wu, Yaxu, Ferguson, James E, Patterson, Cam
PLoS ONE, 2014-02-21;9(2):e89451.
Species: Human
Sample Types: Whole Cells
Applications: Ubiquitination

The spindle and kinetochore-associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit.
Authors: Sivakumar, Sushama, Daum, John R, Tipton, Aaron R, Rankin, Susannah, Gorbsky, Gary J
Mol Biol Cell, 2014-01-08;25(5):594-605.
Species: Human
Sample Types: Cell Lysates
Applications: Bioassay

Ubiquitination increases parkin activity to promote autophagic alpha-synuclein clearance.
Authors: Lonskaya I, Desforges N, Hebron M, Moussa C
PLoS ONE, 2013-12-26;8(12):e83914.
Applications: Enzyme Assay

CXC chemokine receptor 4 signaling upon co-activation with stromal cell-derived factor-1alpha and ubiquitin.
Authors: Tripathi A, Davis J, Staren D, Volkman B, Majetschak M
Cytokine, 2013-12-24;65(2):121-5.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains.
Authors: Liu, Weixiao, Shang, Yonglian, Zeng, Yan, Liu, Chao, Li, Yanchang, Zhai, Linhui, Wang, Pan, Lou, Jizhong, Xu, Ping, Ye, Yihong, Li, Wei
EMBO J, 2013-12-23;33(1):46-61.
Applications: Bioassay

Pin1 modulates ERalpha levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradation.
Authors: Rajbhandari P, Schalper K, Solodin N, Ellison-Zelski S, Ping Lu K, Rimm D, Alarid E
Oncogene, 2013-04-01;33(11):1438-47.
Applications: Bioassay

A pathogen type III effector with a novel E3 ubiquitin ligase architecture.
Authors: Singer, Alexande, Schulze, Sebastia, Skarina, Tatiana, Xu, Xiaohui, Cui, Hong, Eschen-Lippold, Lennart, Egler, Monique, Srikumar, Tharan, Raught, Brian, Lee, Justin, Scheel, Dierk, Savchenko, Alexei, Bonas, Ulla
PLoS Pathog, 2013-01-24;9(1):e1003121.
Applications: Bioassay

Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
Authors: Hebron, Michaeli, Lonskaya, Irina, Sharpe, Kaydee, Weerasinghe, Puwakdan, Algarzae, Norah K, Shekoyan, Ashot R, Moussa, Charbel
J Biol Chem, 2012-12-20;288(6):4103-15.
Applications: Bioassay

Characterization of ML-IAP protein stability and physiological role in vivo.
Authors: Varfolomeev, Eugene, Moradi, Elham, Dynek, Jasmin N, Zha, Jiping, Fedorova, Anna V, Deshayes, Kurt, Fairbrother, Wayne J, Newton, Kim, Le Couter, Jennifer, Vucic, Domagoj
Biochem J, 2012-11-01;447(3):427-36.
Species: Human
Sample Types: Protein
Applications: Bioassay

The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation.
Authors: Lu, Yunzhe, Li, Jiezhi, Cheng, Dongmei, Parameswaran, Balaji, Zhang, Shaohua, Jiang, Zefei, Yew, P Renee, Peng, Junmin, Ye, Qinong, Hu, Yanfen
J Biol Chem, 2012-10-18;287(49):41014-22.
Applications: Ubiquitination

The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.
Authors: Foster S, Morgan D
Mol Cell, 2012-08-30;47(6):921-32.
Applications: Bioassay

ERalpha phosphorylation at Y537 by Src triggers E6-AP-ERalpha binding, ERalpha ubiquitylation, promoter occupancy, and target gene expression.
Authors: Sun J, Zhou W, Kaliappan K, Nawaz Z, Slingerland J
Mol Endocrinol, 2012-08-03;26(9):1567-77.
Species: Human
Sample Types: Protein
Applications: Bioassay

DNA damage-induced heterogeneous nuclear ribonucleoprotein K sumoylation regulates p53 transcriptional activation.
Authors: Pelisch F, Pozzi B, Risso G, Munoz M, Srebrow A
J Biol Chem, 2012-07-23;287(36):30789-99.
Applications: Bioassay

p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO.
Authors: Shibata Y, Oyama M, Kozuka-Hata H, Han X, Tanaka Y, Gohda J, Inoue J
Nat Commun, 2012-01-01;3(0):1061.
Applications: Binding Assay