Home / TGF-beta 3 / Recombinant Human TGF-beta 3 Protein

Recombinant Human TGF-beta 3 Protein

Catalog #: 243-B3
122 Citations Datasheet / COA / SDS

Please see our Next Generation Human Recombinant TGF-beta 3 (8420-B3). It combines R&D Systems quality with scalability that allows for lower price points and a solid supply chain.

Carrier Free

Catalog # Availability Size / Price Qty
243-B3-002/CF
243-B3-010/CF
243-B3-200/CF

With Carrier

Catalog # Availability Size / Price Qty
243-B3-002
243-B3-010
243-B3-200
Recombinant Human TGF-beta 3 Protein
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Product Details
Citations (122)
FAQs
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Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human TGF-beta 3 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389. The ED50 for this effect is 0.0100-0.0400 ng/mL.
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived human TGF-beta 3 protein
Ala301-Ser412 (Tyr340Phe)
Accession #
P10600
N-terminal Sequence
Analysis
Ala301
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
12.7 kDa (monomer)
SDS-PAGE
12 kDa, reducing conditions
24 kDa, non-reducing conditions

Product Datasheets

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243-B3 (with carrier)

Product Datasheet
COA
SDS

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243-B3/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

243-B3

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution Reconstitute at 20 μg/mL in sterile 4 mM HCl containing 1 mg/mL human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

243-B3/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution Reconstitute 2 µg vials at 20 µg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin. Reconstitute 10 µg or larger vials at 50 µg/mL in sterile 4 mM HCl.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: TGF-beta 3

TGF­ beta 3 (transforming growth factor-beta 3) is a member of a TGF-beta superfamily subgroup that is defined by their structural and functional similarities (1-5). TGF-beta 3 and its closely related proteins, TGF-beta 1 and ­-beta 2, act as cellular switches to regulate immune function, cell proliferation, and epithelial­-mesenchymal transition (4, 6, 7). The non-redundant biological effects of TGF-beta 3 include involvement in palatogenesis, chondrogenesis, and pulmonary development (1, 2, 7-9). Human TGF-­ beta 3 cDNA encodes a 412 amino acid (aa) precursor that contains a 20 aa signal peptide and a 392 aa proprotein. The proprotein is processed by a furin­like convertase to generate a 220 aa latency­associated peptide (LAP) and a 112 aa mature TGF­-beta 3 (10, 11). Mature human TGF­-beta 3 shows 100%, 99%, and 98% aa identity with mouse/dog/horse, rat, and pig TGF-­ beta 3, respectively. TGF-beta 3 is secreted as a complex with LAP. This latent form of TGF-beta 3 becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin-1, and a subset of integrins (12). TGF-beta 3 binds with high affinity to TGF-beta RII, a type II serine/threonine kinase receptor. This receptor then phosphorylates and activates type I serine/threonine kinase receptors, TGF-­ beta RI or ALK-­1, to modulate transcription through Smad phosphorylation (13-15). The divergent biological effects exerted by individual TGF-beta isoforms is dependent upon the recruitment of co-receptors (TGF-­ beta RIII and endoglin) and the subsequent initiation of Smad-­dependent or -independent signaling pathways (14, 16, 17).

References
  1. Barrio, M.C. et al. (2014) Cells Tissues Organs. [Epub ahead of print; PMID 24861080].
  2. Doetschman, T. et al. (2012) Genesis 50:59.
  3. Mittl, P.R. et al. (1996) Protein Sci. 5:1261.
  4. Sporn, M.B. (2006) Cytokine Growth Factor Rev. 17:3.
  5. Wahl, S.M. et al. (2006) Immunol. Rev. 213:213.
  6. Chang, H. et al. (2002) Endocr. Rev. 23:787.
  7. Dunker, N. and K. Krieglstein (2000) Eur. J. Biochem. 267:6982.
  8. Jin, J.Z. et al. (2014) Dev. Dyn. [Epub ahead of print; PMID 25104574].
  9. Tang, Q.O. et al. (2009) Expert Opin. Biol Ther. 9:689.
  10. Derynck, R. et al. (1988) EMBO J. 7:3737.
  11. Miyazono, K. et al. (1988) J. Biol. Chem. 263:6407.
  12. Oklu, R. and R. Hesketh (2000) Biochem. J. 352 Pt 3:601.
  13. Cui, X.M. and C.F. Shuler (2000) Int. J. Dev. Biol. 44:397.
  14. de Caestecker, M. (2004) Cytokine Growth Factor Rev. 15:1.
  15. Nakajima, A. et al. (2007) Dev. Dyn. 236:791.
  16. Iwata, J. et al. (2012) J. Clin. Invest. 122:873.
  17. Gatza, C.E. et al. (2010) Cell. Signal. 22:1163.
Long Name
Transforming Growth Factor beta 3
Entrez Gene IDs
7043 (Human); 21809 (Mouse); 25717 (Rat)
Alternate Names
ARVD; ARVD1; FLJ16571; LDS5; RNHF; TGFB3; TGFbeta 3; TGF-beta 3; TGF-beta3; TGF-beta-3; transforming growth factor beta-3; transforming growth factor, beta 3

Citations for Recombinant Human TGF-beta 3 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

122 Citations: Showing 1 - 10
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  1. Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration
    Authors: Saurat, N;Minotti, AP;Rahman, MT;Sikder, T;Zhang, C;Cornacchia, D;Jungverdorben, J;Ciceri, G;Betel, D;Studer, L;
    Cell stem cell
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Secretome Analyses Identify FKBP4 as a GBA1-Associated Protein in CSF and iPS Cells from Parkinson's Disease Patients with GBA1 Mutations
    Authors: Kojima, R;Paslawski, W;Lyu, G;Arenas, E;Zhang, X;Svenningsson, P;
    International journal of molecular sciences
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Designer Fat Cells: Adipogenic Differentiation of CRISPR-Cas9 Genome-Engineered Induced Pluripotent Stem Cells
    Authors: Ely, EV;Kapinski, AT;Paradi, SG;Tang, R;Guilak, F;Collins, KH;
    bioRxiv : the preprint server for biology
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Investigating the Role of TGF-? Signaling Pathways in Human Corneal Endothelial Cell Primary Culture
    Authors: Aouimeur, I;Sagnial, T;Coulomb, L;Maurin, C;Thomas, J;Forestier, P;Ninotta, S;Perrache, C;Forest, F;Gain, P;Thuret, G;He, Z;
    Cells
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  5. Mapping of clonal lineages across developmental stages in human neural differentiation
    Authors: Z You, L Wang, H He, Z Wu, X Zhang, S Xue, P Xu, Y Hong, M Xiong, W Wei, Y Chen
    Cell Stem Cell, 2023-03-17;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  6. Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes
    Authors: AR Dicks, GI Maksaev, Z Harissa, A Savadipour, R Tang, N Steward, W Liedtke, CG Nichols, CL Wu, F Guilak
    Elife, 2023-02-22;12(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Mapping of clonal lineages across developmental stages in human neural differentiation
    Authors: Z You, L Wang, H He, Z Wu, X Zhang, S Xue, P Xu, Y Hong, M Xiong, W Wei, Y Chen
    Cell Stem Cell, 2023;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  8. TGF-beta-Mediated Modulation of Cell-Cell Interactions in Postconfluent Maturing Corneal Endothelial Cells
    Authors: K Santerre, S Cortez Ghi, S Proulx
    Investigative Ophthalmology & Visual Science, 2022-10-03;63(11):3.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Low-Dose-Rate Radiation-Induced Secretion of TGF-beta3 Together with an Activator in Small Extracellular Vesicles Modifies Low-Dose Hyper-Radiosensitivity through ALK1 Binding
    Authors: I Hanson, KE Pitman, U Altanerova, ? Altaner, E Malinen, NFJ Edin
    International Journal of Molecular Sciences, 2022-07-24;23(15):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia
    Authors: L Wang, G Lin, Z Zuo, Y Li, SK Byeon, A Pandey, HJ Bellen
    Oncogene, 2022-07-13;8(28):eabn3326.
    Species: Drosophila melanogaster
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Spotting-based differentiation of functional dopaminergic progenitors from human pluripotent stem cells
    Authors: J Kim, J Jeon, B Song, N Lee, S Ko, Y Cha, P Leblanc, H Seo, KS Kim
    Nature Protocols, 2022-02-09;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Rho/ROCK Inhibition Promotes TGF-beta3-Induced Tenogenic Differentiation in Mesenchymal Stromal Cells
    Authors: M Melzer, S Schubert, SF Müller, J Geyer, A Hagen, S Niebert, J Burk
    Stem Cells International, 2021-10-08;2021(0):8284690.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Bioassay
  13. Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3
    Authors: V Padmanabha, H Liu, G Ciceri, J Jungverdor, G Frishman, J Tchieu, GY Cederquist, I Rothenaign, K Schorpp, L Klepper, RM Walsh, TW Kim, D Cornacchia, A Ruepp, J Mayer, K Hadian, D Frishman, L Studer, M Vincendeau
    Cell Stem Cell, 2021-05-04;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Periostin Short Fragment with Exon 17 via Aberrant Alternative Splicing Is Required for Breast Cancer Growth and Metastasis
    Authors: Y Ikeda-Iwab, Y Taniyama, N Katsuragi, F Sanada, N Koibuchi, K Shibata, K Shimazu, H Rakugi, R Morishita
    Cells, 2021-04-14;10(4):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Priming mesenchymal stem cells with uric acid enhances neuroprotective properties in parkinsonian models
    Authors: HN Kim, JY Shin, DY Kim, JE Lee, PH Lee
    Journal of tissue engineering, 2021-03-30;12(0):2041731421100.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Differentiation, Differentiation
  16. Transformed Canine and Murine Mesenchymal Stem Cells as a Model for Sarcoma with Complex Genomics
    Authors: N Franceschi, B Verbruggen, MA Tryfonidou, AB Kruisselbr, H Baelde, KE de Visser, K Szuhai, AM Cleton-Jan, JVMG Bovée
    Cancers, 2021-03-05;13(5):.
    Species: Canine, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys
    Authors: Y Tao, SC Vermilyea, M Zammit, J Lu, M Olsen, JM Metzger, L Yao, Y Chen, S Phillips, JE Holden, V Bondarenko, WF Block, TE Barnhart, N Schultz-Da, K Brunner, H Simmons, BT Christian, ME Emborg, SC Zhang
    Nature Medicine, 2021-03-01;0(0):.
    Species: Primate - Rhesus macaque
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation
    Authors: KJG Kenswil, P Pisterzi, G Sánchez-Du, C van Dijk, A Lolli, C Knuth, B Vanchin, AC Jaramillo, RM Hoogenboez, MA Sanders, J Feyen, T Cupedo, IG Costa, R Li, EMJ Bindels, K Lodder, B Blom, PK Bos, MJ Goumans, P Ten Dijke, E Farrell, G Krenning, MHGP Raaijmaker
    Cell Stem Cell, 2021-02-08;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use
    Authors: TW Kim, J Piao, SY Koo, S Kriks, SY Chung, D Betel, ND Socci, SJ Choi, S Zabierowsk, BN Dubose, EJ Hill, EV Mosharov, S Irion, MJ Tomishima, V Tabar, L Studer
    Cell Stem Cell, 2021-02-04;28(2):343-355.e5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Repopulation of decellularised articular cartilage by laser-based matrix engraving
    Authors: S Nürnberger, C Schneider, C Keibl, B Schädl, P Heimel, X Monforte, AH Teuschl, M Nalbach, PJ Thurner, J Grillari, H Redl, S Wolbank
    EBioMedicine, 2021-01-19;0(0):103196.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis
    Authors: CL Wu, A Dicks, N Steward, R Tang, DB Katz, YR Choi, F Guilak
    Nature Communications, 2021-01-13;12(1):362.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Control of mesenchymal cell fate via application of FGF-8b in vitro
    Authors: T Otsuka, PY Mengsteab, CT Laurencin
    Stem Cell Research, 2021-01-07;51(0):102155.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Effect of local anesthetics on viability and differentiation of various adult stem/progenitor cells
    Authors: YH Kim, GY Park, N Rabinovitc, S Tarafder, CH Lee
    Stem Cell Res Ther, 2020-09-07;11(1):385.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  24. Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis
    Authors: JW Kim, X Yin, A Jhaldiyal, MR Khan, I Martin, Z Xie, T Perez-Rose, M Kumar, L Abalde-Atr, J Xu, L Chen, SM Eacker, DJ Surmeier, NT Ingolia, TM Dawson, VL Dawson
    Cell Stem Cell, 2020-08-25;27(4):633-645.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Generation of Inducible CRISPRi and CRISPRa Human Stromal/Stem Cell Lines for Controlled Target Gene Transcription during Lineage Differentiation
    Authors: L Chen, K Shi, W Qiu, L Aagaard, M Kassem
    Stem Cells International, 2020-08-19;2020(0):8857344.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Differential regulation of Lipocalin 2 (LCN2) in doxorubicin-resistant 4T1 triple negative breast cancer cells
    Authors: SK Meurer, O Tezcan, T Lammers, R Weiskirche
    Cell. Signal., 2020-08-03;74(0):109731.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
    Cell Stem Cell, 2020-06-19;27(1):125-136.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Mass spectrometric analysis of the in vitro secretome from equine bone marrow-derived mesenchymal stromal cells to assess the effect of chondrogenic differentiation on response to interleukin-1&beta treatment
    Authors: L Bundgaard, A Stensballe, KJ Elbæk, LC Berg
    Stem Cell Res Ther, 2020-05-20;11(1):187.
    Species: Horse
    Sample Types: Whole Cells
    Applications: Cell Culture
  29. Multi-differentiation potential is necessary for optimal tenogenesis of tendon stem cells
    Authors: I Rajpar, JG Barrett
    Stem Cell Res Ther, 2020-04-09;11(1):152.
    Species: Horse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter
    Authors: A Dicks, CL Wu, N Steward, SS Adkar, CA Gersbach, F Guilak
    Stem Cell Res Ther, 2020-02-18;11(1):66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  31. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
    Cell Stem Cell, 2020;27(1):125-136.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors
    Authors: S Mahajani, A Raina, C Fokken, S Kügler, M Bähr
    Cell Death Dis, 2019-11-27;10(12):898.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  33. Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition
    Authors: Y Wu, K Chen, G Xing, L Li, B Ma, Z Hu, L Duan, X Liu
    Sci Adv, 2019-11-27;5(11):eaax7525.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  34. A standalone bioreactor system to deliver compressive load under perfusion flow to hBMSC-seeded 3D chitosan-graphene templates
    Authors: J Lovecchio, P Gargiulo, JL Vargas Lun, E Giordano, ÓE Sigurjónss
    Sci Rep, 2019-11-14;9(1):16854.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  35. Immature mDA neurons ameliorate motor deficits in a 6-OHDA Parkinson's disease mouse model and are functional after cryopreservation
    Authors: D Leitner, M Ramamoorth, M Dejosez, TP Zwaka
    Stem Cell Res, 2019-10-24;41(0):101617.
    Species: Human, Mouse
    Sample Types: In Vitro, Whole Cells
    Applications: Cell Culture, In vitro
  36. Effects of rAAV-Mediated sox9 Overexpression on the Biological Activities of Human Osteoarthritic Articular Chondrocytes in Their Intrinsic Three-Dimensional Environment
    Authors: O Daniels, J Frisch, JK Venkatesan, A Rey-Rico, G Schmitt, M Cucchiarin
    J Clin Med, 2019-10-07;8(10):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Transplanted spleen stromal cells with osteogenic potential support ectopic myelopoiesis
    Authors: HC O'Neill, HK Lim, P Periasamy, L Kumarappan, JKH Tan, TJ O'Neill
    PLoS ONE, 2019-10-04;14(10):e0223416.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons
    Authors: M Riessland, B Kolisnyk, TW Kim, J Cheng, J Ni, JA Pearson, EJ Park, K Dam, D Acehan, LS Ramos-Espi, W Wang, J Zhang, JW Shim, G Ciceri, L Brichta, L Studer, P Greengard
    Cell Stem Cell, 2019-09-19;25(4):514-530.e8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Equine adipose mesenchymal stem cells (eq-ASCs) appear to have higher potential for migration and musculoskeletal differentiation
    Authors: A Shojaee, A Parham, F Ejeian, MH Nasr Esfah
    Res. Vet. Sci., 2019-07-03;125(0):235-243.
    Species: Equine, Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice
    Authors: Y Kawakami, WS Hambright, K Takayama, X Mu, A Lu, JH Cummins, T Matsumoto, T Yurube, R Kuroda, M Kurosaka, FH Fu, PD Robbins, LJ Niedernhof, J Huard
    Mol Ther Methods Clin Dev, 2019-05-30;14(0):64-76.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Hypomorphic mutations of TRIP11 cause odontochondrodysplasia
    Authors: A Wehrle, TM Witkos, S Unger, J Schneider, JA Follit, J Hermann, T Welting, V Fano, M Hietala, N Vatanavich, K Schoner, J Spranger, M Schmidts, B Zabel, GJ Pazour, A Bloch-Zupa, G Nishimura, A Superti-Fu, M Lowe, E Lausch
    JCI Insight, 2019-02-07;4(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. ?2-HS Glycoprotein in Plasma Extracellular Vesicles Inhibits the Osteogenic Differentiation of Human Mesenchymal Stromal Cells In Vitro
    Authors: X Wu, M Ma, P Wang, Z Xie, S Wang, H Su, W Deng, P Feng, C Su, J Yang, J Li, S Tang, Y Wu, H Shen
    Stem Cells Int, 2019-02-07;2019(0):7246479.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Cerebrospinal fluid from Alzheimer's disease patients as an optimal formulation for therapeutic application of mesenchymal stem cells in Alzheimer's disease
    Authors: J Lee, SJ Kwon, JH Kim, H Jang, NK Lee, JW Hwang, JH Kim, JW Chang, DL Na
    Sci Rep, 2019-01-24;9(1):564.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Extracellular vesicles mediate improved functional outcomes in engineered cartilage produced from MSC/chondrocyte cocultures
    Authors: M Kim, DR Steinberg, JA Burdick, RL Mauck
    Proc. Natl. Acad. Sci. U.S.A., 2019-01-15;116(5):1569-1578.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  45. A Novel Biodegradable and Thermosensitive Poly(Ester-Amide) Hydrogel for Cartilage Tissue Engineering
    Authors: TS Fu, YH Wei, PY Cheng, IM Chu, WC Chen
    Biomed Res Int, 2018-12-19;2018(0):2710892.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Bioassay
  46. A Reciprocal Role of the Smad4-Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells
    Authors: JS Park, M Kim, NJ Song, JH Kim, D Seo, JH Lee, SM Jung, JY Lee, J Lee, YS Lee, KW Park, SH Park
    Stem Cells, 2018-12-07;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. TGF?1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism
    Authors: KA de Lima, PB Donate, J Talbot, M Davoli-Fer, RS Peres, TM Cunha, JC Alves-Filh, FQ Cunha
    Cell Death Dis, 2018-11-13;9(11):1130.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing
    Authors: SS Adkar, CL Wu, VP Willard, A Dicks, A Ettyreddy, N Steward, N Bhutani, CA Gersbach, F Guilak
    Stem Cells, 2018-10-31;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. The functional role of chondrogenic stem/progenitor cells: novel evidence for immunomodulatory properties and regenerative potential after cartilage injury
    Authors: J Riegger, HG Palm, RE Brenner
    Eur Cell Mater, 2018-09-14;36(0):110-127.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGF?-dependent manner and limits osteoarthritis in mice
    Authors: H Lin, E Hay, A Latourte, T Funck-Bren, W Bouaziz, HK Ea, AM Khatib, P Richette, M Cohen-Sola
    Sci Rep, 2018-07-11;8(1):10488.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons
    Authors: G Collo, L Cavalleri, M Zoli, U Maskos, E Ratti, E Merlo Pich
    Front Pharmacol, 2018-06-01;9(0):572.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. hPSC-derived Midbrain Dopaminergic Neurons Generated in a Scalable 3-D Biomaterial
    Authors: MM Adil, DV Schaffer
    Curr Protoc Stem Cell Biol, 2018-02-28;44(0):2D.21.1-2D.21.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Restoring tracheal defects in a rabbit model with tissue engineered patches based on TGF-?3-encapsulating electrospun poly(l-lactic acid-co-?-caprolactone)/collagen scaffolds
    Authors: H Jing, B Gao, M Gao, H Yin, X Mo, X Zhang, K Luo, B Feng, W Fu, J Wang, W Zhang, M Yin, Z Zhu, X He, J Zheng
    Artif Cells Nanomed Biotechnol, 2018-02-15;0(0):1-11.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy
    Authors: M Desancé, R Contentin, L Bertoni, T Gomez-Ledu, T Branly, S Jacquet, JM Betsch, A Batho, F Legendre, F Audigié, P Galéra, M Demoor
    Int J Mol Sci, 2018-02-10;19(2):.
    Species: Equine
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Decreased TGFBR3/betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-?-dependent and -independent mechanisms
    Authors: J Nishida, K Miyazono, S Ehata
    Oncogene, 2018-02-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Improvement of the Chondrocyte-Specific Phenotype upon Equine Bone Marrow Mesenchymal Stem Cell Differentiation: Influence of Culture Time, Transforming Growth Factors and Type I Collagen siRNAs on the Differentiation Index
    Authors: T Branly, R Contentin, M Desancé, T Jacquel, L Bertoni, S Jacquet, F Mallein-Ge, JM Denoix, F Audigié, M Demoor, P Galéra
    Int J Mol Sci, 2018-02-01;19(2):.
    Species: Equine
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGF?1 antibody
    Authors: DM Lord, JJ Bird, DM Honey, A Best, A Park, RR Wei, H Qiu
    MAbs, 2018-02-01;0(0):0.
    Species: Human
    Sample Types: Recombinant Protein
  58. miR-29b regulates expression of collagens I and III in chondrogenically differentiating BMSC in an osteoarthritic environment
    Authors: U Mayer, A Benditz, S Grässel
    Sci Rep, 2017-10-16;7(1):13297.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Enhancement of mesenchymal stem cell chondrogenesis with short-term low intensity pulsed electromagnetic fields
    Authors: D Parate, A Franco-Obr, J Fröhlich, C Beyer, AA Abbas, T Kamarul, JHP Hui, Z Yang
    Sci Rep, 2017-08-25;7(1):9421.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
    Authors: K Hino, K Horigome, M Nishio, S Komura, S Nagata, C Zhao, Y Jin, K Kawakami, Y Yamada, A Ohta, J Toguchida, M Ikeya
    J. Clin. Invest., 2017-07-31;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Characterization of single cell derived cultures of periosteal progenitor cells to ensure the cell quality for clinical application
    Authors: S Stich, A Loch, SJ Park, T Häupl, J Ringe, M Sittinger
    PLoS ONE, 2017-05-31;12(5):e0178560.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Exosomes from mesenchymal stem cells induce the conversion of hepatocytes into progenitor oval cells
    Authors: HH Wu, OK Lee
    Stem Cell Res Ther, 2017-05-23;8(1):117.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Effect of microgravity on the mesenchymal stem cell characteristics of limbal fibroblasts
    Authors: SI Pao, KH Chien, HT Lin, MC Tai, JT Chen, CM Liang
    J Chin Med Assoc, 2017-05-18;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. TNF? promotes proliferation of human synovial MSCs while maintaining chondrogenic potential
    Authors: M Shioda, T Muneta, K Tsuji, M Mizuno, K Komori, H Koga, I Sekiya
    PLoS ONE, 2017-05-18;12(5):e0177771.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Clinical-scale expansion of Adipose derived Stromal Cells starting from Stromal Vascular Fraction in a single-use bioreactor: Proof of concept for autologous applications
    Authors: Mélanie Gadelorge
    J Tissue Eng Regen Med, 2017-05-12;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs
    Authors: JM Brunger, A Zutshi, VP Willard, CA Gersbach, F Guilak
    Stem Cell Reports, 2017-04-27;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Dynamics of chromatin accessibility during TGF-?-induced EMT of Ras-transformed mammary gland epithelial cells
    Authors: M Arase, Y Tamura, N Kawasaki, K Isogaya, R Nakaki, A Mizutani, S Tsutsumi, H Aburatani, K Miyazono, D Koinuma
    Sci Rep, 2017-04-26;7(1):1166.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Culture-expanded allogenic adipose tissue-derived stem cells attenuate cartilage degeneration in an experimental rat osteoarthritis model
    Authors: L Mei, B Shen, P Ling, S Liu, J Xue, F Liu, H Shao, J Chen, A Ma, X Liu
    PLoS ONE, 2017-04-18;12(4):e0176107.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Granulocyte macrophage-colony stimulating factor (GM-CSF) significantly enhances articular cartilage repair potential by microfracture
    Authors: MD Truong, BH Choi, YJ Kim, MS Kim, BH Min
    Osteoarthr. Cartil, 2017-03-08;0(0):.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Evaluation of Three Devices for the Isolation of the Stromal Vascular Fraction from Adipose Tissue and for ASC Culture: A Comparative Study
    Authors: J Rodriguez, AS Pratta, N Abbassi, H Fabre, F Rodriguez, C Debard, J Adobati, F Boucher, F Mallein-Ge, C Auxenfans, O Damour, A Mojallal
    Stem Cells Int, 2017-02-22;2017(0):9289213.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Neurotoxic reactive astrocytes are induced by activated microglia
    Authors: SA Liddelow, KA Guttenplan, LE Clarke, FC Bennett, CJ Bohlen, L Schirmer, ML Bennett, AE Mnch, WS Chung, TC Peterson, DK Wilton, A Frouin, BA Napier, N Panicker, M Kumar, MS Buckwalter, DH Rowitch, VL Dawson, TM Dawson, B Stevens, BA Barres
    Nature, 2017-01-18;541(7638):481-487.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. TGF-beta Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner.
    Authors: Elias S, Schmidt A, Kannan V, Andersson J, Tegner J
    Front Immunol, 2016-12-23;7(0):603.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Means of enhancing bone fracture healing: optimal cell source, isolation methods and acoustic stimulation
    BMC Biotechnol, 2016-12-12;16(1):89.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Characterization and Immunomodulatory Effects of Canine Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stromal Cells
    PLoS ONE, 2016-12-01;11(12):e0167442.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  75. EZH2 deletion in early mesenchyme compromises postnatal bone microarchitecture and structural integrity, and accelerates remodeling
    Authors: Sarah Hemming
    FASEB J, 2016-12-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Bromodomain and Extra-terminal Proteins (BET) Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth
    Authors: Weiguo Zou
    J. Biol. Chem., 2016-11-07;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Mesenchymal stem cells from cortical bone demonstrate increased clonal incidence, potency, and developmental capacity compared to their bone marrow-derived counterparts
    J Tissue Eng, 2016-08-16;7(0):2041731416661.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing
    Proc Natl Acad Sci USA, 2016-07-18;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. IL-3 Decreases Cartilage Degeneration by Downregulating Matrix Metalloproteinases and Reduces Joint Destruction in Osteoarthritic Mice
    J Immunol, 2016-05-13;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Aberrant Transforming Growth Factor-? Activation Recruits Mesenchymal Stem Cells During Prostatic Hyperplasia
    Stem Cells Transl Med, 2016-01-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Generation, Characterization, and Multilineage Potency of Mesenchymal-Like Progenitors Derived from Equine Induced Pluripotent Stem Cells.
    Authors: Lepage S, Nagy K, Sung H, Kandel R, Nagy A, Koch T
    Stem Cells Dev, 2015-11-05;25(1):80-9.
    Species: Equine
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Canine Platelet Lysate Is Inferior to Fetal Bovine Serum for the Isolation and Propagation of Canine Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stromal Cells.
    Authors: Russell K, Gibson T, Chong A, Co C, Koch T
    PLoS ONE, 2015-09-09;10(9):e0136621.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Protein-releasing polymeric scaffolds induce fibrochondrocytic differentiation of endogenous cells for knee meniscus regeneration in sheep.
    Authors: Lee C, Rodeo S, Fortier L, Lu C, Erisken C, Mao J
    Sci Transl Med, 2014-12-10;6(266):266ra171.
    Species: Ovine
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs.
    Authors: Liu G, Suzuki K, Li M, Qu J, Montserrat N, Tarantino C, Gu Y, Yi F, Xu X, Zhang W, Ruiz S, Plongthongkum N, Zhang K, Masuda S, Nivet E, Tsunekawa Y, Soligalla R, Goebl A, Aizawa E, Kim N, Kim J, Dubova I, Li Y, Ren R, Benner C, del Sol A, Bueren J, Trujillo J, Surralles J, Cappelli E, Dufour C, Esteban C, Izpisua Belmonte J
    Nat Commun, 2014-07-07;5(0):4330.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling.
    Authors: Jakobsen R, Ostrup E, Zhang X, Mikkelsen T, Brinchmann J
    PLoS ONE, 2014-05-09;9(5):e96615.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. microRNA-495 inhibits chondrogenic differentiation in human mesenchymal stem cells by targeting Sox9.
    Authors: Lee S, Yoon D, Paik S, Lee K, Jang Y, Lee J
    Stem Cells Dev, 2014-04-28;23(15):1798-808.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. In vitro model suggests oxidative stress involved in keratoconus disease.
    Authors: Karamichos D, Hutcheon A, Rich C, Trinkaus-Randall V, Asara J, Zieske J
    Sci Rep, 2014-04-09;4(0):4608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Induction of immunomodulatory monocytes by human mesenchymal stem cell-derived hepatocyte growth factor through ERK1/2.
    Authors: Chen P, Liu K, Hsu P, Wei C, Bai C, Ho L, Sytwu H, Yen B
    J Leukoc Biol, 2014-04-08;96(2):295-303.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells.
    Authors: Zhang H, Yin Y, Wang G, Liu Z, Liu L, Sun F
    Sci Rep, 2014-03-03;4(0):4260.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage.
    Authors: Brunger J, Huynh N, Guenther C, Perez-Pinera P, Moutos F, Sanchez-Adams J, Gersbach C, Guilak F
    Proc Natl Acad Sci U S A, 2014-02-18;111(9):E798-806.
    Applications: Bioassay
  91. Semaphorin 3A induces mesenchymal-stem-like properties in human periodontal ligament cells.
    Authors: Wada, Naohisa, Maeda, Hidefumi, Hasegawa, Daigaku, Gronthos, Stan, Bartold, Peter Ma, Menicanin, Danijela, Fujii, Shinsuke, Yoshida, Shinichi, Tomokiyo, Atsushi, Monnouchi, Satoshi, Akamine, Akifumi
    Stem Cells Dev, 2014-02-10;23(18):2225-36.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA.
    Authors: Belzile, Jean-Phi, Stark, Thomas J, Yeo, Gene W, Spector, Deborah
    J Virol, 2014-01-22;88(8):4021-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. A role for topographic cues in the organization of collagenous matrix by corneal fibroblasts and stem cells.
    Authors: Karamichos D, Funderburgh M, Hutcheon A, Zieske J, Du Y, Wu J, Funderburgh J
    PLoS ONE, 2014-01-21;9(1):e86260.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  94. Human bone marrow-derived mesenchymal stem cells display enhanced clonogenicity but impaired differentiation with hypoxic preconditioning.
    Authors: Boyette, Lisa B, Creasey, Olivia A, Guzik, Lynda, Lozito, Thomas, Tuan, Rocky S
    Stem Cells Transl Med, 2014-01-16;3(2):241-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis.
    Authors: Brady K, Dickinson S, Guillot P, Polak J, Blom A, Kafienah W, Hollander A
    Stem Cells Dev, 2013-12-04;23(5):541-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. CD146 expression on mesenchymal stem cells is associated with their vascular smooth muscle commitment.
    Authors: Espagnolle N, Guilloton F, Deschaseaux F, Gadelorge M, Sensebe L, Bourin P
    J Cell Mol Med, 2013-11-04;18(1):104-14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Sox9-regulated miRNA-574-3p inhibits chondrogenic differentiation of mesenchymal stem cells.
    Authors: Guerit D, Philipot D, Chuchana P, Toupet K, Brondello J, Mathieu M, Jorgensen C, Noel D
    PLoS ONE, 2013-04-23;8(4):e62582.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  98. MicroRNA-based promotion of human neuronal differentiation and subtype specification.
    Authors: Stappert L, Borghese L, Roese-Koerner B, Weinhold S, Koch P, Terstegge S, Uhrberg M, Wernet P, Brustle O
    PLoS ONE, 2013-03-18;8(3):e59011.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression.
    Authors: Lund, Troy C, Kobs, Amanda J, Kramer, Ashley, Nyquist, Mick, Kuroki, Marcos T, Osborn, John, Lidke, Diane S, Low-Nam, Shalini, Blazar, Bruce R, Tolar, Jakub
    PLoS ONE, 2013-03-08;8(3):e58945.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  100. Human embryonic stem cell-derived mesenchymal stroma cells (hES-MSCs) engraft in vivo and support hematopoiesis without suppressing immune function: implications for off-the shelf ES-MSC therapies.
    Authors: Li O, Tormin A, Sundberg B, Hyllner J, Le Blanc K, Scheding S
    PLoS ONE, 2013-01-29;8(1):e55319.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  101. Molecular characterization of prospectively isolated multipotent mesenchymal progenitors provides new insight into the cellular identity of mesenchymal stem cells in mouse bone marrow.
    Authors: Qian H, Badaloni A, Chiara F, Stjernberg J, Polisetti N, Nihlberg K, Consalez G, Sigvardsson M
    Mol Cell Biol, 2012-11-26;33(4):661-77.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Transforming growth factor Beta 3 is required for excisional wound repair in vivo.
    Authors: Le M, Naridze R, Morrison J, Biggs L, Rhea L, Schutte B, Kaartinen V, Dunnwald M
    PLoS ONE, 2012-10-26;7(10):e48040.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  103. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012-07-26;487(7408):505-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. TGF-beta-induced apoptosis of B-cell lymphoma Ramos cells through reduction of MS4A1/CD20.
    Authors: Kawabata K, Ehata S, Komuro A, Takeuchi K, Miyazono K
    Oncogene, 2012-06-04;32(16):2096-106.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Primary Mesenchymal Stem and Progenitor Cells from Bone Marrow Lack Expression of CD44 Protein.
    Authors: Qian H, Le Blanc K, Sigvardsson M
    J. Biol. Chem., 2012-05-31;287(31):25795-807.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Age-related changes in rat bone-marrow mesenchymal stem cell plasticity.
    Authors: Asumda FZ, Chase PB
    BMC Cell Biol., 2011-10-12;12(0):44.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
    Authors: Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV
    J. Biol. Chem., 2011-07-07;286(34):30034-46.
    Species: Human, Mouse
    Sample Types: Recombinant Protein
    Applications: Surface Plasmon Resonance
  108. An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.
    Authors: Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY, Lindeman GJ, Shannon MF, Drew PA, Khew-Goodall Y, Goodall GJ
    Mol. Biol. Cell, 2011-03-16;22(10):1686-98.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis.
    Authors: Moransard M, Sawitzky M, Fontana A, Suter T
    Glia, 2010-04-01;58(5):559-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos.
    Authors: Kawaguchi J, Nichols J, Gierl MS, Faial T, Smith A
    Development, 2010-03-01;137(5):693-704.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells.
    Authors: English K, Ryan JM, Tobin L, Murphy MJ, Barry FP, Mahon BP
    Clin. Exp. Immunol., 2009-02-03;156(1):149-60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation, Differentiation
  112. Autologous stem cell regeneration in craniosynostosis.
    Authors: Moioli EK, Clark PA, Sumner DR, Mao JJ
    Bone, 2007-10-17;42(2):332-40.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  113. Transforming growth factor-beta in the brain enhances fat oxidation via noradrenergic neurons in the ventromedial and paraventricular hypothalamic nucleus.
    Authors: Fujikawa T, Matsumura S, Yamada H, Inoue K, Fushiki T
    Brain Res., 2007-08-09;1173(0):92-101.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  114. Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.
    Authors: Neurohr C, Nishimura SL, Sheppard D
    Am. J. Respir. Cell Mol. Biol., 2006-03-30;35(2):252-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta.
    Authors: Nagineni CN, Kutty V, Detrick B, Hooks JJ
    J. Cell. Physiol., 2005-04-01;203(1):35-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Derivation of midbrain dopamine neurons from human embryonic stem cells.
    Authors: Perrier AL, Tabar V, Barberi T, Rubio ME, Bruses J, Topf N, Harrison NL, Studer L
    Proc. Natl. Acad. Sci. U.S.A., 2004-08-13;101(34):12543-8.
    Species: Human, Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads.
    Authors: Wen FQ, Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T, Ertl R, Terasaki Y, Manouilova L, Rennard SI
    Am. J. Respir. Cell Mol. Biol., 2004-01-12;30(6):816-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein.
    Authors: Mogi K, Goto M, Ohno E, Azumi Y, Takeuchi S, Toyoizumi R
    Int. J. Dev. Biol., 2003-02-01;47(1):15-29.
    Species: Xenopus
    Sample Types: In Vivo
    Applications: In Vivo
  119. Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells.
    Authors: Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI
    Am. J. Physiol. Lung Cell Mol. Physiol., 2002-05-01;282(5):L1049-56.
    Applications: ELISA (Standard)
  120. Induction of a hypertrophic growth status of coronary smooth muscle cells is associated with an overexpression of TGF-beta.
    Authors: Schmidt A, 2019, Gopfert C, Vlodavsky I, Volker W, Buddecke E
    101211, 2002-03-01;81(3):138-44.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Transforming growth factor beta expression in human placenta and placental bed during early pregnancy.
    Authors: Simpson H, 2019, Robson SC, Bulmer JN, Barber A, Lyall F
    6897, 2002-01-01;23(1):44-58.
    Applications: ELISA (Standard)
  122. Isoform specificity of commercially-available anti-TGF-beta antibodies.
    Authors: Mozes MM, Hodics T, Kopp JB
    J. Immunol. Methods, 1999-05-27;225(1):87-93.
    Applications: Western Blot

FAQs

  1. Is Recombinant Human TGF-beta 3 Protein (Catalog # 243-B3) latent or active?

    • The sequence for this protein is Spodoptera frugiperda, Sf 21 (baculovirus)-derived human TGF-beta 3 protein, Ala301-Ser412 (Tyr340Phe), Accession # P10600. Ala301-Ser412 is associated with the active form of the protein and does not include the latency-associated peptide sequence (amino acids 24-300).

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